Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/j.tim.2017.11.002
Document author version
Title (Primary) Human gut microbiome: function matters
Author Heintz-Buschart, A.; Wilmes, P.
Source Titel Trends in Microbiology
Year 2018
Department BOOEK; iDiv
Volume 26
Issue 7
Page From 563
Page To 574
Language englisch
Keywords multi-omics; functional microbiome; metagenomics; metatranscriptomics; metaproteomics; microbiome variability and individuality
UFZ wide themes RU1;

The human gut microbiome represents a complex ecosystem contributing essential functions to its host. Recent large-scale metagenomic studies have provided insights into its structure and functional potential. However, the functional repertoire which is actually contributed to human physiology remains largely unexplored. Here, by leveraging recent omics datasets, we challenge current assumptions regarding key attributes of the functional gut microbiome, in particular with respect to its variability. We further argue that the closing of existing gaps in functional knowledge should be addressed by a most-wanted gene list, the development and application of molecular and cellular high-throughput measurements, the development and sensible use of experimental models, as well as the direct study of observable molecular effects in the human host.

Persistent UFZ Identifier
Heintz-Buschart, A., Wilmes, P. (2018):
Human gut microbiome: function matters
Trends Microbiol. 26 (7), 563 - 574 10.1016/j.tim.2017.11.002