Lectures to the TOPIC: “Modernizing Hazard and PBT assessment with New Approach Methodologies” within the framework of the CoModHaz project.

Date: Monday, October 27, 1-4 pm
Venue: KUBUS, hall 2

Short Agenda:
Part I: State of the art in PBT assessment and hazard screening
13:00 Alternative test methods in current REACH and CLP guidance for PBT assessment and research needs (Anu Kapanen, Environmental Chemicals Agency ECHA)
13:30 Regulatory work on UV-Benzotriazoles (Juliane Ackermann, German Environmental Agency UBA)
14:00 Same but different – The Swiss approach to chemical safety (Eszter Simon & Andreas Buser, Swiss Federal Office of the Environment FOEN)
14:30 break

Part II: CoModHaz: Co-Creation process for the modernization of chemical hazard indicators
14:45 The CoModHaz project (Beate Escher, UFZ Zelltox)
14:55 In vitro bioassay test battery for the hazard screening of chemicals (Sarah Stevens, UFZ Zelltox)
15:10 Case study on bisphenol A alternatives (Vanessa Srebny, UFZ Zelltox)
15:25 The challenges of dosing very hydrophobic chemicals in in vitro bioassays (Stefan Saretz, UFZ Zelltox)
15:35 Coupling Toxicity & Biodegradation (Yohan Seol, UFZ Zelltox)
15:45 In vitro bioassay testing of very hydrophobic chemicals and biodegradation products (Eunhye Bae, UFZ Zelltox)
15:55 Conclusion

Short Project Abstract: The assessment of chemical hazards is essential for the safe management of chemicals, as outlined in the "European Chemicals Strategy for Sustainability". Helmholtz researchers have proposed two new hazard indicators that go beyond the traditional assessment of persistence, bioaccumulation and toxicity (PBT). These two new indicators, called Cumulative Toxicity Equivalents (CTE) and Persistent Toxicity Equivalents (PTE), will be tested as part of the CoModHaz project. The project comprises case studies developed in cooperation with authorities, NGOs and industry and focuses on chemicals that are difficult to assess. The UFZ research platform CITEPro will be used for high-throughput bioassays. The project aims to validate the new indicators in practice and remove barriers to their implementation. This should ultimately contribute to safer and more sustainable chemical assessments.

Host: Prof. Beate Escher / Department Cell Toxicology 

Topic: Chronic Exposure to Glyphosate-Based Herbicides Decreases Semen Quality, which in turn Disrupts Immunoregulation in the Female Genital Tract and Affects Fetal Development

Host: Prof. Ana Zenclussen / Department of Environmental Immunology

Start: 10:00 AM Via Zoom

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Topic: Deep phenotyping in insect ecotoxicology: from the insect apocalypse to the stress response

Host: Wibke Busch
Venue: Building 7.3, room 7.013
Start: 1 pm

Topic: The role of slow radical chemistry in limiting environment persistence of recalcitrant contaminants

and

Protein interactions of the organophosphate plasticizer and flame retardant triphenyl phosphate

Host: Beate Escher
Venue: Building 7.3, room 7.013
Start: 10 am

Topic: Adressing mixture exposure in environmental health: Challenges and approaches

Host: Prof. Annika Jahnke / Department Exposure Science
Venue: KUBUS Hall 2 and via Zoom
Start: 10 am  

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Topic: Intelligent Identification of High-Risk Chemicals in Regional Aquatic Environments

Host: Prof. Beate Escher / Department Cell Toxicology
Venue: Building 7.3, Hall 7.013 and via Zoom
Start: 9 am

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Topic: Unraveling the toxicity of 6PPD-quinone across fishes of commercial, cultural, and ecological importance

Host: Prof. Werner Brack / Department Exposure Science
Venue: KUBUS Hall 2
Start: 10 am

Topic: What does Fluorination do? Exploring the Environmental Partition Properties of PFAS

Host: Prof. Beate Escher / Department Cell Toxicology
Venue: KUBUS Hall 1A and via Zoom
Start: 1 pm

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Topic: sox9a and sox9b as critical regulators of dioxin-induced neurovascular toxicity

Host: Prof. Tamara Tal / Department Ecotoxicology
Venue: KUBUS, Hall 2
Start: 10 am

Topic: Beyond the Nucleus: Membrane Steroid Receptors and Endocrine Disrupting Chemicals

Host: Prof. Tamara Tal / Department Ecotoxicology
Venue: KUBUS, Hall 1A
Start: 10 am

Topic: Challenges and opportunities for the use of NAMS within NextGen environmental risk assessment of cosmetic ingredients

Host: Prof. Beate Escher / Department Cell Toxicology
Venue: Building 1.0, R. 254 (VTS left side) and Zoom
Start: 3.15 pm

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Kenncode: 521083

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Topic: Halogenated-hydroxycyclopentenediones: mutagenicity and reactivity of a new class of disinfection by-products in drinking water

Host: Prof. Ana Zenclussen / Department Environmental Immunology
Venue: KUBUS, Saal 1A and Zoom
Start: 10 am

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Topic: The promising model amphipod Parhyale hawaiensis: From EVO-DEVO to Ecotoxicology

Host: Prof. Werner Brack / Department Exposure Science
Venue: KUBUS, Saal 1A and ZOOM
Start: 10 am

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18.01.2024 Dr. Wibke Busch / Helmholtz Centre for Environmental Research UFZ, Leipzig
Topic: Dealing with chemical mixtures - hazard assessment with toxicogenomics, monitoring data, and data-driven approaches
Host: Prof. Werner Brack / Research Unit Chemicals in the Environment
Venue: Kubus, Hall 1A
Start: 1 pm

29.04.2024 Prof. Elaine Leslie / University of Alberta, Canada
Topic: The Influence of Selenium on Arsenic Transport by Human Hepatocytes
Host: Dr. Till Luckenbach / Department Ecotoxicology
Venue: Zoom
Start: 2.30 pm

13.05.2024 Prof. Sally Gaw / University of Canterbury, New Zealand
Topic: Consumer products as a source of diffuse environmental contamination
Host: Dr. Dusan Materic / Department Environmental Analytical Chemistry
Venue: KUBUS, Hall 2 and via Zoom
Start: 1 pm 

15.05.2024 Prof. David Volz / University of California Riverside, USA
Topic: Human Exposure and Health Effects of Organophosphate-Based Flame Retardants
Host: Prof. Tamara Tal / Department Ecotoxicology
Venue: Kubus, Hall 1A
Start: 10 am 

14.08.2024 Paloma de Oro-Carretero / Complutense University of Madrid, Spain
Topic: Bioaccumulation: walking in the 3Rs pathway
Host: Dr. Luise Henneberger / Department Cell Toxicology
Venue: Kubus, Hall 1A
Start: 1 pm

22.10.2024 Prof. Heather Leslie / Heather Leslie Projects, Amsterdam
Topic: Current environmental plastic and associated chemicals research and paths forward
Host: Prof. Annika Jahnke / Department Exposure Science
Venue: ZOOM
Start: 1.10 pm

23.10.2024 Prof. Nestor Etxebarria Loizate / University of the Basque Country, Spain
Topic: One Health Living lab @ Plentzia Marine Station
Host: Dr. Iker Alvarez Mora / Department Exposure Science
Venue: Kubus, Hall 1CD and via ZOOM
Start: 1 pm

12.11.2024 Prof. John Colbourne / University of Birmingham, United Kingdom
Topic: Searching for the evolutionary origins of chemical toxicity
Host: Dr. Stefan Scholz / Department Ecotoxicology
Venue: Kubus, Hall 1B
Start: 10 am

26.11.2024 Associate Prof. Damien Callahan / School of Life and Environmental Science, Deakin University, Australia
Topic: Pesticide Watch: findings from an Australian river monitoring program supported by citizen scientists
Host: Dr. Martin Krauss / Department Exposure Science
Venue: Building 1.0, Room 254
Start: 10 am

12.12.2024 Prof. Kai Wang / Chinese Academy of Agricultural Sciences, Beijing, China
Topic: Actions for a healthy honey bee colonies: What are we doing to combat emerging environmental pollutants
Host: Prof. Martin von Bergen / Department Molecular Toxicology
Venue: Zoom
Start: 10 am

30.01.2023 Julie Robitaille / OECD and INRS Quebec, Canada
Topic: Toward monitoring endocrine disrupting chemicals in freshwater using bioassays: from developing a strategy for wastewater in the province of Quebec, Canada, to building OECD recommendations
Host: Prof. Beate Escher / Department of Cell Toxicology and Prof. Werner Brack / RU Cite
Venue: Kubus Hall 1A and Zoom
Start: 10 am

07.02.2023 Katharina Halbach and Sue Martina Starke / Spurenstoffzentrum des Bundes
Topic: The German Centre for Micropollutants: Goals and Tasks
Host: Prof. Werner Brack / RU Cite and Beate Escher / Department Cell Toxicology
Venue: Kubus Hall 2
Start: 2 pm

09.03.2023 Ass.-Prof. Michael Zumstein / University Vienna, Austria
Topic: Extracellular enzymes in wastewater and their potential to transform anthropogenic chemicals
Host: Prof. Beate Escher / Department of Cell Toxicology and Dr. Lukas Wick / Department of Environmental Microbiology (Research Unit of Environmental Engineering and Biotechnology)
Venue: KUBUS Hall 2
Start: 1 pm

06.04.2023 Ass.-Prof. Bethanie Carney Almroth / University of Gothenburg, Sweden
Topic: The planetary scale of the plastics problem
Host: Dr. Eric Carmona Martinez / Department of Effect-Directed Analysis
Venue: KUBUS Hall 1CD
Start: 10 am

18.04.2023 Ass.-Prof. Laura Revell / University of Canterbury, New Zealand
Topic: Airborne microplastics in a changing climate
Host: Dr. Dusan Materic / Department Analytical Chemistry
Venue: KUBUS Hall 1CD and Zoom
Start: 10 am

11.05.2023 Assoc. Prof. Amy M. Padula / University of California, San Francisco School of Medicine
Topic: Prenatal per- and polyfluoroalkyl substances (PFAS) and adverse child health outcomes
Host: Prof. Ana Zenclussen / Department of Environmental Immunology
Venue: KUBUS Hall 1A
Start: 11 am

08.06.2023 Dr. Andrea Ebert / Department of Analytical Environmental Chemistry, Helmholtz Centre for Environmental Research Leipzig
Topic: Transport kinetics and partitioning in biological systems - a toolbox for quantitative understanding
Host: Prof. Kai-Uwe Goss / Department of Analytical Environmental Chemistry
Venue: Kubus, Hall 2 and Zoom
Start: 10 am

14.07.2023 Prof. Jing You / Jinan University Guangzhou, China
Topic: Event driven taxonomy: AI in Identifying causative contaminants in chemical mixtures
Host: Prof. Beate Escher / Department of Cell Toxicology
Venue: KUBUS Hall 2
Start: 11 am

27.07.2023 Dr. Zhongli Chen / Chongqing University, China
Topic: Challenge and opportunity: the eco-environmental issues of the China’s Three Gorges Reservoir
Host: Prof. Annika Jahnke / Department of Ecological Chemistry
Venue: KUBUS Hall 1a and Zoom
Start: 10 am

28.08.2023 Prof. Satoshi Endo / National Institute for Environmental Studies (NIES), Japan
Topic: It's not just about pore water free concentration: Exposure to organic contaminants in sediment toxicity tests
Host: Prof. Kai-Uwe Goss / Department of Analytical Environmental Chemistry
Venue: Kubus, Hall 1a and Zoom
Start: 10 am

14.09.2023 Dr. Michael Zimmermann / European Molecular Biology Laboratory (EMBL), Heidelberg
Topic: Identifying gut microbiome contributions to drug metabolism and carcinogen toxicity
Host: Prof. Martin von Bergen / Department of Molecular Systems Biology
Venue: Kubus, Hall 1a
Start: 10 am

09.11.2023 Dr. Jo Nyffeler / Helmholtz Centre for Environmental Research UFZ, Leipzig
Topic: Application of Cell Painting for chemical hazard evaluation in support of screening-level assessments
Host: Prof. Werner Brack / Research Unit Chemicals in the Environment
Venue: Kubus, Hall 1A and Zoom
Start: 10 am

18.01.2022 Prof. Ondine von Ehrenstein / UCLA - POSTPONED
Topic: "Environmental exposures and children’s health: report from research in California and Bangladesh"
Host: Prof. Rolf Altenburger / Research Unit CITE
Venue: Zoom
Start: 3 pm

24.01.2022 Natascha Schmidt / Mediterranean Institute of Oceanography, Marseille, France
Topic: “Microplastics and associated organic contaminants in the aquatic environment”
Host: Prof. Thorsten Reemtsma / Department of Analytical Chemistry
Venue: Zoom
Start: 10 am

25.01.2022 Ass.-Prof. Carsten Prasse / Johns Hopkins Whiting School of Engineering and the Bloomberg School of Public Health, USA
Topic: "Reactivity-directed analysis (RDA): A novel approach for the identification of toxicants in (drinking) water"
Host: Prof. Beate Escher / Department of Cell Toxicology
Venue: Zoom
Start: 3 pm

01.02.2022 Dr. Dusan Materic / Institute for Marine and Atmospheric Research, Utrecht University, The Netherlands
Topic: “Nanoplastics measurement by TD-PTR-MS- from the high Alps to the polar regions and deep sea”
Host: Prof. Thorsten Reemtsma / Department of Analytical Chemistry
Venue: Zoom
Start: 2 pm

12.04.2022 Prof. Peter Fantke / Technical University of Denmark
Topic: "Modelling chemical pollution to support a safe and sustainable chemicals management"
Host: PD Dr. Werner Brack / Department of Effect Directed Analysis
Venue: Kubus Hall 2 and via Zoom
Start: 10 am

21.06.2022 Prof. Traidl-Hoffmann / University Augsburg and Helmholtz Zentrum München
Topic: „Multidimensional interaction of environmental and health - paving the way towards personalized prevention“
Host: Prof. Ana Zenclussen / Department of Environmental Immunology
Venue: Zoom
Start: 10 am

21.09.2022 Dr. Natalie Aneck-Hahn / University of Pretoria, South Africa
Topic: „A South African perspective on effect-based methods for water quality assessment“
Host: Prof. Beate Escher / Department of Cell Toxicology
Venue: Kubus, Hall 2
Start: 10 am
 

26.03.2021 Prof. Barbara Kasprzyk-Hordern / Department of Chemistry at the University of Bath and a co-director of Water and Innovation Research Centre
Topic: The concept of wastewater-based epidemiology and its rapid advances
Host: PD Dr. Werner Brack / Effect-Directed Analysis
Venue: virtual, Zoom
Start: 1 pm

22.04.2021 María Julia Culzoni / Faculty of Biochemistry and Biological Sciences (FBCB), National University of Litoral (UNL), Argentina
Topic: Analytical platforms for human biomonitoring
Host: Prof. Ana Zenclussen / Environmental Immunology
Venue: virtual, Zoom
Start: 3 pm

04.05.2021 Dr. Sonia Dagnino / Faculty of Medicine, School Public Health, Imperial College London, UK
Topic: Understanding Chemical exposure and health outcomes with Exposomics
Host: PD Dr. Werner Brack / Effect-Directed Analysis
Venue: virtual, Zoom
Start: 10 am

21.05.2021 Prof. Matthias Blüher / Helmholtz Institute for Metabolic, Obesity and Vascular Research; HI-MAG Director and Head of Clinical Obesity Research Group; W3 Professor in Clinical Obesity Research at the University of Leipzig
Topic: Obesity – another symptom of an “unhealthy environment”?
Host: Prof. Beate Escher / Cell Toxicology
Venue: virtual, Zoom
Start: 9 am

04.06.2021 Ralf Ebinghaus & Marcus Lange / Helmholtz-Zentrum Hereon, Geesthacht
Topic: "The Coastal Pollution Toolbox – a Topic 4 product within POFIV"
Host: PD Dr. Werner Brack / Effect-Directed Analysis
Venue: virtual, Zoom
Start: 9 am

01.07.2021 Dr. Jake O’Brien / Research Fellow at the Queensland Alliance for Environmental Health Sciences (QAEHS)
Topic: "The benefits of conducting wastewater sampling during a population census - case study using the Australian Census"
Host: Prof. Beate Escher / Cell Toxicology
Venue: virtual, Zoom
Start: 10 am

12.07.2021 Dr. Qiuguo Fu / EAWAG, Switzerland
Topic: "Fate processes and biological effects of pharmaceuticals in the aquatic organisms: A case study with diclofenac"
Host: Prof. Thorsten Reemstma / Analytical Chemistry
Venue: virtual, Zoom
Start: 3 pm

09.09.2021 Dr. Tewes Tralau / Bundesministerium für Risikoforschung (BfR)
Topic: "The challenge of microbiome-mediated toxicity – are we up for it?"
Host: Prof. Martin von Bergen / Department of Molecular Systems Biology
Venue: virtual, Zoom
Start: 10 am

18.11.2021 Dr. Matthias Egger / The Ocean Cleanup, Netherlands
Topic: "Fate of floating plastic debris in the ocean"
Host: Prof. Annika Jahnke / Department of Ecological Chemistry
Venue: Zoom
Start: 10 am

07.12.2021 Dr. Johanna Nyffeler / US EPA Durham and Oak Ridge Institute for Science and Education (ORISE), USA
Topic: "Imaging-based phenotypic profiling for high-throughput chemical screening at the U.S. Environmental Protection Agency"
Host: Prof. Beate Escher / Department of Cell Toxicology
Venue: Zoom
Start: 3 pm

16.12.2021 Dr. Martin Blettler / INALI; CONICET-UNL, Argentina
Topic: “Macroplastic research in freshwater systems: opening up the scene”
Host: Dr. Katrin Wendt-Potthoff / Department of Lake Research
Venue: Zoom
Start: 10:30 am

20.02.2020 Prof. Yolanda Picó / University of Valencia, Spain
Topic: Gender’s perspective application in environmental studies
Host: Dr. Eric Carmona Martinez / Effect-Directed Analysis
Venue: KUBUS, hall 2AB
Start: 9:30 am

14.05.2020 Prof. Matthias Liess / Helmholtz Centre for Environmental Research – UFZ
Topic: Kleingewässermonitoring - Nationwide Monitoring of Small Streams
Online-Meeting via GoTo
Start: 10 am
Host: Prof. Rolf Altenburger / Research Unit Chemicals in the Environment

25.06.2020 Dr. Igor Tetko / Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Topic: Beyond traditional QSAR: Artificial Intelligence and machine learning for chemical space exploration, synthesis and activity prediction
face-to-face-Meeting / Online-Meeting via GoTo
Host: Prof. Kai-Uwe Goss / Analytical Environmental Chemistry
Venue: KUBUS, hall 2AB
Start: 10 am

16.09.2020 Prof. Markus Große Ophoff & Dr. Klaus Günter Steinhäuser / BUND AK Umweltchemikalien und Toxikologie
Vortrag und Diskussion zum BUND Positionspapier "Herausforderungen für eine nachhaltige Stoffpolitik"
face-to-face-Meeting / Online-Meeting via GoTo
Host: Prof. Rolf Altenburger / Research Unit Chemicals in the Environment
Venue: KUBUS, hall 1AB
Start: 3 pm

12.11.2020 Prof. Sebastian Böcker / University Jena
Topic: SIRIUS, CANOPUS and COSMIC: Turning tandem mass spectra into metabolite structure information
Online-Meeting via Zoom
Host: Dr. Tobias Schulze / Effect-Directed Analysis
Start: 10 am

03.12.2020 Prof. Inna Sokolova / Institute of Biological Sciences, University Rostock
Topic: Bioenergetics in environmental adaptation and stress tolerance of aquatic ectotherms: Linking ecology and physiology in multistressor landscape
Online-Meeting via Zoom
Host: Dr. Till Luckenbach / Bioanalytical Ecotoxicology
Start: 10 am

31.01.2019 PD Dr. Werner Brack / Helmholtz-Centre for Environmental Research - UFZ
Topic: "SOLUTIONS for monitoring, assessment and prioritization of micropollutants in European river basins"
Host: PD Dr. Werner Brack
Venue: Kubus Hall 1CD
Start: 4 pm

28.02.2019 Prof. Janine Felix / Erasmus MC, University Medical Center Rotterdam
Topic: "Early-life programming of life course health – The Generation R Study"
Host: Dr. Gunda Herberth
Venue: Kubus Hall 1A
Start: 4 pm

07.03.2019 Dr. Dries Knapen / University of Antwerp
Topic: "Developing mechanism-specific endpoints for use in fish embryo and early life stage testing"
Host: Dr. Stefan Scholz
Venue: Kubus Hall 1A
Start: 2:30 pm

26.04.2019 Dr. Peter Turnbaugh / University of California San Francisco - UCSF
Topic: "Precision medicine goes microscopic: zooming in on the role of the microbiome in drug response"
Host: Prof. Martin von Bergen
Venue: Kubus Hall 1 A
Start: 1 pm

17.05.2019 Jos van Gils / Deltares Netherlands
Topic: "Advanced modelling tools in support of management of water quality: trends and challenges"
Host: PD Dr. Werner Brack
Venue: Kubus Hall 1 A
Start: 10 am

27.06.2019 Prof. Chih C. Lai / University St. Thomas, St. Paul, USA
Topic: "Deep Learning and Convolutional Neural Networks: Case Studies"
Host: Dr. Stefan Scholz and Dr. Jörg Hackermüller
Venue: KUBUS hall 1A
Start: 1 pm

01.07.2019 Dr. Alex Avdeef / in-ADME RESEARCH
Topic: "Perspectives in Solubility: Measurement and Interpretation. Data Mining for Equilibrium Solubility of Sparingly Soluble Compounds"
Host: Prof. Beate Escher and Prof. Kai-Uwe Goss
Venue: KUBUS hall 1A
Start: 3 pm

23.08.2019 Prof. Jung-Hwan Kwon / Div. of Env. Science and Ecological Engineering, Korea Univ Seoul
Topic: "Potential risks of associated organic pollutants with microplastics: equilibrium and kinetics"
Host: Prof. Beate Escher and Prof. Kai-Uwe Goss
Venue: Kubus hall 1A
Start: 11 am

17.10.2019 Prof. Leo Posthuma / RIVM Utrecht, Netherlands
Topic: "SOLUTIONS-NL: a knowledge impulse to prevent and reduce chemical pollution of surface waters in the Netherlands"
Host: Dr. Werner Brack
Venue: Kubus hall 1CD
Start: 12:30 pm

27.11.2019 Dr. Tamara Tal / Helmholtz-Centre for Environmental Research - UFZ
Topic: "Investigating microbiome-chemical interactions in zebrafish"
Host: Dr. Stefan Scholz
Venue: Kubus hall 1C
Start: 10 am

19.12.2019 Prof. Nikolaos Thomaidis / Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Greece
Topic: "High Resolution Mass Spectrometric Non-Target Screening of emerging contaminants in the environment: Development of methods and workflows and their application in wide-scope monitoring studies and exposure assessment"
Host: Dr. Tobias Schulze
Venue: KUBUS hall 1A
Start: 12:30 pm 

20.09.2018 Dr. Tamara Tal / U.S. Environmental Protection Agency - US EPA
Topic: "Modification of environmental contaminants by intestinal microbiota"
Host: Prof. Martin von Bergen
Venue: Kubus Hall 1B
Start: 10 am

23.10.2018 Dr. Edward J. Perkins / U.S. Corps of Engineers, Army Engineer Research and Development Center - ERDC
Topic: "Merging toxicogenomics and quantitative modeling with the Adverse Outcome Pathway framework to assess chemical hazards"
Host: Dr. Stefan Scholz
Venue: Kubus Hall 2
Start: 10 am

29.11.2018 Dr. Oliver Lindtner / Bundesinstitut für Risikobewertung - BfR
Topic: "Die BfR-MEAL-Studie: Beispiele zur Stoffauswahl"
Host: Dr. Gunda Herberth
Venue: Building 4.0, Room 101
Start: 4 pm