Details zur Publikation

Kategorie Textpublikation
Referenztyp Zeitschriften
DOI 10.1016/j.tim.2017.11.002
Volltext Autorenversion
Titel (primär) Human gut microbiome: function matters
Autor Heintz-Buschart, A.; Wilmes, P.
Quelle Trends in Microbiology
Erscheinungsjahr 2018
Department BOOEK; iDiv
Band/Volume 26
Heft 7
Seite von 563
Seite bis 574
Sprache englisch
Keywords multi-omics; functional microbiome; metagenomics; metatranscriptomics; metaproteomics; microbiome variability and individuality
UFZ Querschnittsthemen RU1;

The human gut microbiome represents a complex ecosystem contributing essential functions to its host. Recent large-scale metagenomic studies have provided insights into its structure and functional potential. However, the functional repertoire which is actually contributed to human physiology remains largely unexplored. Here, by leveraging recent omics datasets, we challenge current assumptions regarding key attributes of the functional gut microbiome, in particular with respect to its variability. We further argue that the closing of existing gaps in functional knowledge should be addressed by a most-wanted gene list, the development and application of molecular and cellular high-throughput measurements, the development and sensible use of experimental models, as well as the direct study of observable molecular effects in the human host.

dauerhafte UFZ-Verlinkung
Heintz-Buschart, A., Wilmes, P. (2018):
Human gut microbiome: function matters
Trends Microbiol. 26 (7), 563 - 574 10.1016/j.tim.2017.11.002