|DOI / URL||link|
|Title (Primary)||Toxicity testing with Vibrio fischeri: A comparison between the long term (24 h) and the short term (30 min) bioassay|
|Author||Backhaus, T.; Froehner, K.; Altenburger, R.; Grimme, L.H.;|
The acute bioluminescence inhibition assay using the marine bacterium Vihrio fischeri as the test organism is a widely used short term toxicity test. This paper compares the standard 30 minutes test with a 24 h assay using the same organism and the same test parameter. For that purpose concentration-response relationships were determined for a set of selected substances, reflecting different modes and mechanisms of action.
The results indicate a severe blind spot of the acute biotest: The toxicity of certain specifically acting chemicals is drastically underestimated here, while the chronic biotest gives a more reliable estimate of the toxicity of these substances.
|Persistent UFZ Identifier||https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=9149|
|Backhaus, T., Froehner, K., Altenburger, R., Grimme, L.H. (1997):
Toxicity testing with Vibrio fischeri: A comparison between the long term (24 h) and the short term (30 min) bioassay
Chemosphere 35 (12), 2925 - 2938