Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1007/BF02986390
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Title (Primary) Antiestrogenic activity of anthropogenic and natural chemicals
Author Navas, J.M.; Segner, H.
Journal Environmental Science and Pollution Research
Year 1998
Department OEC; COE
Volume 5
Issue 2
Page From 75
Page To 82
Language englisch
Abstract A number of natural and man-made chemicals possess antiestrogenic activity, i.e. they antagonize a broad spectrum of estrogen-induced responses in vertebrates. Examples of antiestrogens include dioxin, furan and PCB congeners, certain PAHs, pesticides and indol-3-carbinol derivatives. Major mechanisms of antiestrogenicity are antagonistic action of chemicals at the estrogen receptor, or binding of chemicals to the arylhydrocarbon (Ah) receptor and subsequent interaction with estrogen-responsive genes. Toxicological consequences resulting from antiestrogenic activity have not been conclusively demonstrated to date, although antiestrogenic compounds could critically affect sensitive reproductive and developmental processes.
Persistent UFZ Identifier
Navas, J.M., Segner, H. (1998):
Antiestrogenic activity of anthropogenic and natural chemicals
Environ. Sci. Pollut. Res. 5 (2), 75 - 82