Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1007/BF02986390 |
| Document | Shareable Link |
| Title (Primary) | Antiestrogenic activity of anthropogenic and natural chemicals |
| Author | Navas, J.M.; Segner, H. |
| Source Titel | Environmental Science and Pollution Research |
| Year | 1998 |
| Department | OEC; COE |
| Volume | 5 |
| Issue | 2 |
| Page From | 75 |
| Page To | 82 |
| Language | englisch |
| Abstract | A number of natural and man-made chemicals possess antiestrogenic activity, i.e. they antagonize a broad spectrum of estrogen-induced responses in vertebrates. Examples of antiestrogens include dioxin, furan and PCB congeners, certain PAHs, pesticides and indol-3-carbinol derivatives. Major mechanisms of antiestrogenicity are antagonistic action of chemicals at the estrogen receptor, or binding of chemicals to the arylhydrocarbon (Ah) receptor and subsequent interaction with estrogen-responsive genes. Toxicological consequences resulting from antiestrogenic activity have not been conclusively demonstrated to date, although antiestrogenic compounds could critically affect sensitive reproductive and developmental processes. |
| Navas, J.M., Segner, H. (1998): Antiestrogenic activity of anthropogenic and natural chemicals Environ. Sci. Pollut. Res. 5 (2), 75 - 82 10.1007/BF02986390 |
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