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Title (Primary) Differing effect of protein isolates from different cultivars of blue lupin on plasma lipoproteins of hypercholesterolemic rats
Author Bettzieche, A.; Brandsch, C.; Schmidt, M.; Weisse, K.; Eder, K.; Stangl, G.I.;
Journal Bioscience Biotechnology and Biochemistry
Year 2008
Department IMMU;
Volume 72
Issue 12
Language englisch;
Keywords lupin protein; plasma lipoprotein; hepatic gene expression; rat
Abstract Protein from white lupin is capable of lowering plasma lipids. We investigated in this study the effect of total protein extracts (TPEs) from different cultivars of blue lupin (Probor, Vitabor and Boregine) and a-/ß-conglutin from Boregine on the plasma lipids of rats. Rats were fed on a hypercholesterolemic diet containing either lupin protein (50 g/kg) or casein (50 g/kg) for 17 d. The rats fed with TPE from Vitabor and a-/ß-conglutin had lower triglyceride concentrations in the plasma (-24% and -21%, respectively) and very-low-density lipoprotein (VLDL; -40% and -29%, respectively) than the rats fed with casein. TPE from Vitabor was also capable of lowering low-density lipoprotein (LDL) cholesterol (-37%). In the liver of the rats fed with TPE from Vitabor, the expression of the genes involved in triglyceride and cholesterol synthesis was down-regulated. This study shows that the Vitabor cultivar of blue lupin had the most beneficial effect on plasma lipids which was presumed to have been caused by the down-regulation of genes involved in lipid synthesis.
ID 804
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=804
Bettzieche, A., Brandsch, C., Schmidt, M., Weisse, K., Eder, K., Stangl, G.I. (2008):
Differing effect of protein isolates from different cultivars of blue lupin on plasma lipoproteins of hypercholesterolemic rats
Biosci. Biotechnol. Biochem. 72 (12), 3114 - 3121