Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/S0043-1354(01)00026-4
Title (Primary) Selective degradation of ibuprofen and clofibric acid in two model river biofilm systems
Author Winkler, M.; Kopf, G.; Lawrence, J.R.; Neu, T.R.
Journal Water Research
Year 2001
Department FLOEK; GM
Volume 35
Issue 13
Page From 3197
Page To 3205
Language englisch
Keywords biofilms, rivers, ibuprofen, clofibric acid, biodegradation, metabolites
Abstract A field survey indicated that the Elbe and Saale Rivers were contaminated with both clofibric acid and ibuprofen. In Elbe River water we could detect the metabolite hydroxy-ibuprofen. Analyses of the city of Saskatoon sewage effluent discharged to the South Saskatchewan river detected clofibric acid but neither ibuprofen nor any metabolite. Laboratory studies indicated that the pharmaceutical ibuprofen was readily degraded in a river biofilm reactor. Two metabolites were detected and identified as hydroxy–and carboxy–ibuprofen. Both metabolites were observed to degrade in the biofilm reactors. However, in human metabolism the metabolite carboxy–ibuprofen appears and degrades second whereas the opposite occurs in biofilm systems. In biofilms the pharmacologically inactive stereoisomere of ibuprofen is degraded predominantly. In contrast, clofibric acid was not biologically degraded during the experimental period of 21 days. Similar results were obtained using biofilms developed using waters from either the South Saskatchewan or Elbe River. In a sterile reactor no losses of ibuprofen were observed. These results suggested that abiotic losses and adsorption played only a minimal role in the fate of the pharmaceuticals in the river biofilm reactors.
Persistent UFZ Identifier
Winkler, M., Kopf, G., Lawrence, J.R., Neu, T.R. (2001):
Selective degradation of ibuprofen and clofibric acid in two model river biofilm systems
Water Res. 35 (13), 3197 - 3205