Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1002/tox.1019
Title (Primary) Assessment of toxicity and mutagenicity in air particulate matter from an urban industrial area in the coast of the Rio de la Plata
Author Müller, A.; Alzuet, P.; Herbarth, O.; Ronco, A.
Journal Environmental Toxicology
Year 2001
Department EXPOEPID
Volume 16
Issue 2
Page From 151
Page To 157
Language englisch
Keywords air pollution; PAHs; mutagenicity; Ames test; toxicity; Tetrahymena pyriformis
Abstract Chemical characterization and effects assessment of semivolatile organic compounds in organic extracts from air particulate matter from the region of the greater La Plata area was undertaken. Effects covered the study of mutagenicity with the Ames test (Salmonella typhimurium TA100 and TA98 strains with metabolic activation by S9) and cytotoxicity using the Tetrahymena pyriformis test system (growth rate, cell volume, and cell respiration). Chemical analysis of organic extracts was done using gas chromatography. Results demonstrate the presence of polycyclic aromatic hydrocarbons (PAH) in the matrix, high mutagenicity, and cytotoxicity. A higher mutagenic activity detected with TA98 and TA100 strains is associated with an increment of total PAH and total five or six ring PAH content, respectively. Linked with it, a PAH dependent toxicity on Tetrahymena pyriformis has been observed. This cell system proved to be very sensitive. From the results obtained with the cell respiration assay with T. pyriformis it appears that uncoupling agents are present in the samples. The results of this study indicate that air particulate matter from the Rio de La Plata area contains significant genotoxic and cytotoxic activity probably due to the presence of PAHs.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=6631
Müller, A., Alzuet, P., Herbarth, O., Ronco, A. (2001):
Assessment of toxicity and mutagenicity in air particulate matter from an urban industrial area in the coast of the Rio de la Plata
Environ.Toxicol. 16 (2), 151 - 157