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Reference Category Journals
DOI 10.1002/etc.5620220512
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Title (Primary) Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals: performance evaluation in a ring test
Author Tolls, J.; Bodo, K.; De Felip, E.; Dujardin, R.; Kim, Y.H.; Moeller-Jensen, L.; Mullee, D.; Nakajima, A.; Paschke, A.; Pawliczek, J.B.; Schneider, J.; Tadeo, J.L.; Tognucci, A.C.; Webb, J.; Zwijzen, A.C.
Source Titel Environmental Toxicology and Chemistry
Year 2003
Department OEC
Volume 22
Issue 5
Page From 1051
Page To 1057
Language englisch
Keywords Slow-stirring method; Ring test; Hydrophobic chemicals; n-Octanol/water partition coefficient
Abstract

The n-octanol/water partition coefficient (P-ow) is one of the most important parameters employed for estimating a chemical's environmental fate and toxicity. The currently adopted test guidelines for its determination do not allow for reliable determination of log P-ow greater than 5. The slow-stirring experiment, in contrast, has been demonstrated to provide reliable log P-ow data up to log P-ow of 8.3. To validate this method and to obtain its approval as an official Organization for Economic Cooperation and Development (Paris, France) test guideline, a ring test was performed to evaluate the accuracy and precision of the slow-stirring experiment for determination of log P-ow particularly for highly hydrophobic compounds. Up to 15 volunteer laboratories tested 1,2,3,4-tetrachlorobenzene, hexachlorobenzene, 2,2',3,3',5,5',6,6'-octachlorobiphenyl, and decachlorobiphenyl (4.5 < log P-ow < 8.2). The ring-test results for the respective chemicals were 4.62, 5.50, 7.39, and 8.18. The results deviated by less than 0.1 log P-ow units from the reference log P-ow In addition, the relative standard deviations of log P-ow were less than 2%. Using the protocol of the ring test, log P-ow of p,p'-DDT was determined to be 6.24 +/- 0.05 (mean +/- standard deviation). In combination, these results indicate that the slow-stirring method is precise and accurate and, thus, allows for reliable determination of log P-ow of highly hydrophobic chemicals.

Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=5252
Tolls, J., Bodo, K., De Felip, E., Dujardin, R., Kim, Y.H., Moeller-Jensen, L., Mullee, D., Nakajima, A., Paschke, A., Pawliczek, J.B., Schneider, J., Tadeo, J.L., Tognucci, A.C., Webb, J., Zwijzen, A.C. (2003):
Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals: performance evaluation in a ring test
Environ. Toxicol. Chem. 22 (5), 1051 - 1057 10.1002/etc.5620220512