Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1007/s00791-008-0118-9
Title (Primary) Numerical simulation of drug release from collagen matrices by enzymatic degradation
Author Radu, F.A.; Bause, M.; Fries, W.; Knabner, P.; Metzmacher, I.
Source Titel Computing and Visualization in Science
Year 2009
Department ENVINF
Volume 12
Issue 8
Page From 409
Page To 420
Language englisch
Abstract Biodegradable collagen matrices have become a promising alternative to synthetic polymers as drug delivery systems for sustained release. Previously, a mathematical model describing water penetration, matrix swelling and drug release by diffusion from dense collagen matrices was introduced and tested (cf. Radu et al. in J. Pharm. Sci. 91:964-972, 2002). However, enzymatic matrix degradation influences the drug release as well. Based on experimental studies (cf. Metzmacher in Enzymatic degradation and drug release behavior of dense collagen implants. Ph.D. thesis, LMU University of Munich, 2005), a mathematical model is presented here that describes drug release by collagenolytic matrix degradation. Existence and uniqueness of a solution of the model equations is reviewed. A mixed Raviart-Thomas finite element discretization for solving the coupled system of partial and ordinary differential equations is proposed and analyzed theoretically. The model is verified by a comparison of numerically calculated and experimentally measured data and, in particular, investigated by a parameter sensitivity study. For illustration, some concentration profiles of a two-dimensional simulation are shown. This research was supported by the Deutsche Forschungsgemeinschaft (DFG, Germany) Grant FR 1089/4-1.
Persistent UFZ Identifier
Radu, F.A., Bause, M., Fries, W., Knabner, P., Metzmacher, I. (2009):
Numerical simulation of drug release from collagen matrices by enzymatic degradation
Comput. Visual. Sci. 12 (8), 409 - 420 10.1007/s00791-008-0118-9