Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1177/1420326X03035167
Title (Primary) Indoor mould exposure reduces Th1 reactivity in early childhood
Author Lehmann, I.; Müller, A.; Diez, U.; Richter, M.; Wallach, S.; Sierig, G.; Seiffart, A.; Wetzig, H.; Borte, M.; Herbarth, O.
Source Titel Indoor and Built Environment
Year 2003
Volume 12
Issue 4
Page From 231
Page To 233
Language englisch
Keywords Indoor mould; Allergy; Children; T cells; IFN-g; IL-4; Th1 cells; Th2 cells
Abstract A birth cohort study (LARS - Leipzig Allergy Risk Children Study) was used to investigate the influence of indoor mould exposure on T cell function in early childhood. T cell cytokines (IFN-g, IL-4) were analysed in a sub-group of the LARS cohort (birth: n = 39, 6 months: n = 11, 12 months: n = 50, 36 months: n = 33). Mould burden was assessed by analysis of questionnaires completed at the birth of the child and measurement of indoor mould spores was carried out when the children were 3 years old. Children whose parents reported mould burden or dampness in their dwellings at the time of birth showed lower amounts of IFN-g producing Th1 cells during the first year of life (significant at 12 months) in comparison to unexposed children. The capacity to produce IL-4 was not altered, however. When the children were 3 years old, an association between measured indoor mould and suppressed Th1 reactivity was observed. The data suggest that indoor mould exposure is associated with reduced Th1 reactivity in early childhood.
Persistent UFZ Identifier
Lehmann, I., Müller, A., Diez, U., Richter, M., Wallach, S., Sierig, G., Seiffart, A., Wetzig, H., Borte, M., Herbarth, O. (2003):
Indoor mould exposure reduces Th1 reactivity in early childhood
Indoor Built Environ. 12 (4), 231 - 233 10.1177/1420326X03035167