Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1007/s10295-005-0254-x
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Title (Primary) White biotechnology for green chemistry: fermentative 2-oxocarboxylic acids as novel building blocks for subsequent chemical syntheses
Author Stottmeister, U.; Aurich, A.; Wilde, H.; Andersch, J.; Schmidt, S.; Sicker, D.
Source Titel Journal of Industrial Microbiology & Biotechnology
Year 2005
Department UBZ; UBT_alt
Volume 32
Issue 11-12
Page From 651
Page To 664
Language englisch
Abstract

Functionalized compounds, which are difficult to produce by classical chemical synthesis, are of special interest as biotechnologically available targets. They represent useful building blocks for subsequent organic syntheses, wherein they can undergo stereoselective or regioselective reactions. “White Biotechnology” (as defined by the European Chemical Industry [http://www.europabio.org/white_biotech.htm], as part of a sustainable “Green Chemistry,”) supports new applications of chemicals produced via biotechnology. Environmental aspects of this interdisciplinary combination include:

  • Use of renewable feedstock

  • Optimization of biotechnological processes by means of:

  • New “high performance” microorganisms

  • On-line measurement of substrates and products in bioreactors

  • Alternative product isolation, resulting in higher yields, and lower energy demand

  • In this overview we describe biotechnologically produced pyruvic, 2-oxopentaric and 2-oxohexaric acids as promising new building blocks for synthetic chemistry. In the first part, the microbial formation of 2-oxocarboxylic acids (2-OCAs) in general, and optimization of the fermentation steps required to form pyruvic acid, 2-oxoglutaric acid, and 2-oxo-d-gluconic acid are described, highlighting the fundamental advantages in comparison to chemical syntheses. In the second part, a set of chemical formula schemes demonstrate that 2-OCAs are applicable as building blocks in the chemical synthesis of, e.g., hydrophilic triazines, spiro-connected heterocycles, benzotriazines, and pyranoic amino acids. Finally, some perspectives are discussed.

    Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=3825
    Stottmeister, U., Aurich, A., Wilde, H., Andersch, J., Schmidt, S., Sicker, D. (2005):
    White biotechnology for green chemistry: fermentative 2-oxocarboxylic acids as novel building blocks for subsequent chemical syntheses
    J. Ind. Microbiol. Biotechnol. 32 (11-12), 651 - 664 10.1007/s10295-005-0254-x