Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1126/science.1102226
Title (Primary) Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes
Author Seshadri, R.; Adrian, L.; Fouts, D.E.; Eisen, J.A.; Phillippy, A.M.; Methe, B.A.; Ward, N.L.; Nelson, W.C.; Deboy, R.T.; Khouri, H.M.; Kolonay, J.F.; Dodson, R.J.; Daugherty, S.C.; Brinkac, L.M.; Sullivan, S.A.; Madupu, R.; Nelson, K.T.; Kang, K.H.; Impraim, M.; Tran, K.; Robinson, J.M.; Forberger, H.A.; Fraser, C.M.; Zinder, S.H.; Heidelberg, J.F.
Source Titel Science
Year 2005
Department ISOBIO
Volume 307
Issue 5706
Page From 105
Page To 108
Language englisch
Abstract Dehalococcoides ethenogenes is the only bacterium known to reductively dechlorinate the groundwater pollutants, tetrachloroethene (PCE) and trichloroethene, to ethene. Its 1,469,720-base pair chromosome contains large dynamic duplicated regions and integrated elements. Genes encoding 17 putative reductive dehalogenases, nearly all of which were adjacent to genes for transcription regulators, and five hydrogenase complexes were identified. These findings, plus a limited repertoire of other metabolic modes, indicate that D. ethenogenes is highly evolved to utilize halogenated organic compounds and H-2. Diversification of reductive dehalogenase functions appears to have been mediated by recent genetic exchange and amplification. Genome analysis provides insights into the organism's complex nutrient requirements and suggests that an ancestor was a nitrogen-fixing autotroph
Persistent UFZ Identifier
Seshadri, R., Adrian, L., Fouts, D.E., Eisen, J.A., Phillippy, A.M., Methe, B.A., Ward, N.L., Nelson, W.C., Deboy, R.T., Khouri, H.M., Kolonay, J.F., Dodson, R.J., Daugherty, S.C., Brinkac, L.M., Sullivan, S.A., Madupu, R., Nelson, K.T., Kang, K.H., Impraim, M., Tran, K., Robinson, J.M., Forberger, H.A., Fraser, C.M., Zinder, S.H., Heidelberg, J.F. (2005):
Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes
Science 307 (5706), 105 - 108 10.1126/science.1102226