Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1021/acs.estlett.5c00836 |
Licence  |
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| Title (Primary) | Prenatal exposure to emerging pesticides and childhood allergy risk: A mixture assessment in an urban birth cohort |
| Author | Gómez-Olarte, S.
; Röder, S.
; Borte, M.; Krauss, M.
; Zenclussen, A.; Brack, W.; Herberth, G.
; Huber, C. |
| Source Titel | Environmental Science & Technology Letters |
| Year | 2025 |
| Department | IMMU; EXPO |
| Volume | 12 |
| Issue | 12 |
| Page From | 1611 |
| Page To | 1617 |
| Language | englisch |
| Topic | T9 Healthy Planet |
| Supplements | Supplement 1 |
| Keywords | asthma; eczema; wheezing; pesticide metabolites; weighted quantile sum (WQS) regression |
| Abstract | Pesticide gestational exposure may
contribute to the development of allergies in childhood, yet evidence on
its health impact on urban populations remains limited. This study
investigates the association between prenatal exposure to individual and
mixed pesticides and allergic outcomes, including asthma, wheezing, and
eczema, at age 6 in 387 mother-child pairs from the German prospective
cohort LiNA. Forty pesticides and metabolites were detected in urine
during pregnancy through nontargeted screening, and 11 were selected
(detection rate ≥ 17%) for further analysis. Multivariable logistic
regression models adjusted for covariates revealed statistically
significant associations between dihydroxy-pyrimethanil and asthma (aOR =
1.35, 95% CI: 1.02–1.79), and fluazifop-desbuthyl and wheezing (aOR =
1.14, 95% CI: 1.01–1.30). No significant associations were observed for
eczema. The weighted quantile sum (WQS) regression showed that higher
pesticide coexposures significantly increased wheezing odds (aOR = 2.08,
95% CI: 1.21–3.56). The main components of the WQS index were
fluazifop-desbuthyl, flonicamid, hydroxy-metazachlor, and
terbuthylazine, accounting for 67% of the overall mixture effect. These
findings suggest that prenatal exposure to pesticides, likely from
dietary sources, may increase the risk of childhood asthma and wheezing.
Replication studies in populations with comparable pesticide exposures,
along with experimental mechanistic validation, will strengthen the
understanding of the observed associations. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=31557 |
| Gómez-Olarte, S., Röder, S., Borte, M., Krauss, M., Zenclussen, A., Brack, W., Herberth, G., Huber, C. (2025): Prenatal exposure to emerging pesticides and childhood allergy risk: A mixture assessment in an urban birth cohort Environ. Sci. Technol. Lett. 12 (12), 1611 - 1617 10.1021/acs.estlett.5c00836 |
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