Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1021/envhealth.4c00215 |
Licence  |
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| Title (Primary) | A virus aerosol chamber study: The impact of UVA, UVC, and H2O2 on airborne viral transmission |
| Author | Nasrabadi, A.M.; Eckstein, D.; Mettke, P.; Ghanem, N.; Kallies, R.; Schmidt, M.; Mothes, F.; Schaefer, T.; Graefe, R.; Bandara, C.D.; Maier, M.; Liebert, U.G.; Richnow, H.; Hermann, H. |
| Source Titel | Environment & Health |
| Year | 2025 |
| Department | MIBITECH; TECH; AME |
| Language | englisch |
| Topic | T7 Bioeconomy |
| Supplements | https://pubs.acs.org/doi/suppl/10.1021/envhealth.4c00215/suppl_file/eh4c00215_si_001.pdf |
| Keywords | Aerosolized Virus Transmission; Mucin; UVA; UVC; Hydrogen Peroxide (H2O2); Virus Aerosol Chamber; Quantitative PCR (qPCR) |
| Abstract | The COVID-19 pandemic highlighted the urgent need to control airborne virus transmission, particularly in indoor environments with limited ventilation. This study evaluates the effectiveness of UVA and UVC irradiation, along with hydrogen peroxide (H2O2), in inactivating aerosolized viruses. A 19 m3 virus aerosol simulation chamber, replicating indoor conditions, was used to simulate human respiratory emissions by aerosolizing Escherichia phage T4 (T4 phages) embedded in a pig mucin medium that mimics respiratory aerosols. Results showed a clear, dose-dependent reduction in viral genome copies with UVC exposure, where a dose of 129.9 mJ/cm2 reduced over 99% of the viral genome copies. Although less efficient, UVA still contributed to virus inactivation, reducing detectable phages to 20% at 513.30 J/cm2. Mucin provided a protective effect, making virus removal more challenging. Hydrogen peroxide enhanced disinfection, with 1.6 ppm reducing viral genome copies by 78%, and higher concentrations (up to 16 ppm) achieving over 99% reduction in the dark condition. The combination of UVA/UVC with H2O2 further enhanced disinfection, eliminating detectable virus genome copies entirely. These findings underscore the potential for using combined UV light and chemical treatments to effectively mitigate airborne viral transmission in enclosed spaces. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=30571 |
| Nasrabadi, A.M., Eckstein, D., Mettke, P., Ghanem, N., Kallies, R., Schmidt, M., Mothes, F., Schaefer, T., Graefe, R., Bandara, C.D., Maier, M., Liebert, U.G., Richnow, H., Hermann, H. (2025): A virus aerosol chamber study: The impact of UVA, UVC, and H2O2 on airborne viral transmission Environ. Health 10.1021/envhealth.4c00215 |
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