Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1007/s12268-024-2261-3 |
Licence  |
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| Title (Primary) | Hin zu effizienter biokatalytischer Oxyfunktionalisierung von Steroiden [Towards efficient biocatalytic oxyfuntionalization of steroids] |
| Author | Bertelmann, C.; Bühler, B. |
| Source Titel | Biospektrum |
| Year | 2024 |
| Department | MIBITECH |
| Volume | 30 |
| Issue | 5 |
| Page From | 593 |
| Page To | 595 |
| Language | deutsch |
| Topic | T7 Bioeconomy |
| Abstract | Biocatalytic steroid hydroxylation processes are highly relevant for the pharmaceutical industry but are still limited by low specific activities and stabilities. For testosterone hydroxylation, high activities were achieved with recombinant Escherichia coli containing a highly active CYP450-BM3 variant and outer membrane porins. Enzyme instability and substrate mass transfer were identified as further limitations, for which biocatalyst and reaction engineering strategies are discussed. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=30259 |
| Bertelmann, C., Bühler, B. (2024): Hin zu effizienter biokatalytischer Oxyfunktionalisierung von Steroiden [Towards efficient biocatalytic oxyfuntionalization of steroids] Biospektrum 30 (5), 593 - 595 10.1007/s12268-024-2261-3 |
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