Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1016/j.immuni.2021.09.002 |
| Title (Primary) | Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 |
| Author | Krämer, B.; Knoll, R.; Bonaguro, L.; ToVinh, M.; Raabe, J.; Astaburuaga-García, R.; Schulte-Schrepping, J.; Nunes da Rocha, U.; Rosenstiel, P., et al. |
| Source Titel | Immunity |
| Year | 2021 |
| Department | UMB |
| Volume | 54 |
| Issue | 11 |
| Page From | 2650 |
| Page To | 2669.e14 |
| Language | englisch |
| Topic | T7 Bioeconomy |
| Supplements | https://www.sciencedirect.com/science/article/pii/S1074761321003654?via%3Dihub#app2 |
| Keywords | NK cells; COVID-19; scRNA-seq; proteomics; severe; moderate; type 1 IFN; TNF; lung fibrosis; antiviral |
| Abstract | Longitudinal analyses of the innate immune system, including the earliest time points, are essential to understand the immunopathogenesis and clinical course of coronavirus disease (COVID-19). Here, we performed a detailed characterization of natural killer (NK) cells in 205 patients (403 samples; days 2 to 41 after symptom onset) from four independent cohorts using single-cell transcriptomics and proteomics together with functional studies. We found elevated interferon (IFN)-α plasma levels in early severe COVD-19 alongside increased NK cell expression of IFN-stimulated genes (ISGs) and genes involved in IFN-α signaling, while upregulation of tumor necrosis factor (TNF)-induced genes was observed in moderate diseases. NK cells exert anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity but are functionally impaired in severe COVID-19. Further, NK cell dysfunction may be relevant for the development of fibrotic lung disease in severe COVID-19, as NK cells exhibited impaired anti-fibrotic activity. Our study indicates preferential IFN-α and TNF responses in severe and moderate COVID-19, respectively, and associates a prolonged IFN-α-induced NK cell response with poorer disease outcome. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29564 |
| Krämer, B., Knoll, R., Bonaguro, L., ToVinh, M., Raabe, J., Astaburuaga-García, R., Schulte-Schrepping, J., Nunes da Rocha, U., Rosenstiel, P., et al. (2021): Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 Immunity 54 (11), 2650 - 2669.e14 10.1016/j.immuni.2021.09.002 |
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