Publication Details |
Category | Text Publication |
Reference Category | Journals |
DOI | 10.1016/j.jaci.2006.07.014 |
Title (Primary) | Direct evidence for a critical role of CD30 in the development of allergic asthma |
Author | Polte, T.; Behrendt, A.K.; Hansen, G. |
Source Titel | Journal of Allergy and Clinical Immunology |
Year | 2006 |
Department | IMMU |
Volume | 118 |
Issue | 4 |
Page From | 942 |
Page To | 948 |
Language | englisch |
Keywords | Asthma; costimulation; TH2 cells; CD30; immunotherapy |
Abstract | Background: CD30 is a costimulatory molecule belonging to the TNF receptor superfamily that is expressed on activated T and B cells. Several studies have demonstrated a positive correlation between expression of CD30 or increased levels of soluble CD30 and the development and severity of allergic diseases. However, thus far, the evidence for a role of CD30 in allergic diseases, such as asthma, is only indirect. Objective: The aim of the study was to directly investigate the role of CD30 in a murine asthma model. Methods: CD30-deficient (B6.129P2-Tnfrsf8(tm1Mak)/J) and wild-type (WT) mice were immunized to ovalbumin (OVA) to induce an asthma-like phenotype and compared in our murine asthma model. Moreover, CD30/CD30 ligand signaling was blocked in OVA-immunized WT animals by using mAbs against CD30 receptor and its ligand, CD153. Results: The absence of CD30 in OVA-immunized CD30-deficient mice resulted in significantly reduced airway inflammation, serum IgE levels, and T(H)2 cytokine levels. The same effect was observed when CD30/CD153 signaling was blocked in OVA-immunized WT animals with mAbs against CD30 or CD30 ligand. Conclusion: Our results directly demonstrate that CD30/CD153 interaction plays an important role in the induction of TH2 cell-mediated allergic asthma. Clinical implications: These findings provide evidence for a role of the costimulatory molecule CD30 in allergic asthma |
Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=2919 |
Polte, T., Behrendt, A.K., Hansen, G. (2006): Direct evidence for a critical role of CD30 in the development of allergic asthma J. Allergy Clin. Immunol. 118 (4), 942 - 948 10.1016/j.jaci.2006.07.014 |