Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1016/j.tiv.2024.105828 |
| Title (Primary) | Comparative in vitro toxicological effects of water-soluble and insoluble components of atmospheric PM2.5 on human lung cells |
| Author | Wei, Y.; Chen, Y.; Hong, Y.; Chen, J.; Li, H.-B.; Li, H.; Yao, X.; Mehmood, T.; Feng, X.; Luo, X.-S. |
| Source Titel | Toxicology In Vitro |
| Year | 2024 |
| Department | TECH |
| Volume | 98 |
| Page From | art. 105828 |
| Language | englisch |
| Topic | T7 Bioeconomy |
| Keywords | Air pollution; Cytotoxicity; Chemical composition; Spatial and temporal differences; Health risks |
| Abstract | Fine particulates in city air significantly impact human health, but the hazardous compositional mechanisms are still unclear. Besides the toxicity of environmental PM2.5 to in vitro human lung epithelial cells (A549), the independent cytotoxicity of PM2.5-bound water-soluble (WS-PM2.5) and water-insoluble (WIS-PM2.5) fractions were also compared by cell viability, oxidative stress (reactive oxygen species, ROS), and inflammatory injury (IL-6 and TNF-α). The cytotoxicity of PM2.5 varied significantly by sampling season and place, with degrees greater in winter and spring than in summer and autumn, related to corresponding trend of air PM2.5 level, and also higher in industrial than urban site, although their PM2.5 pollution levels were comparable. The PM2.5 bound metals (Ni, Cr, Fe, and Mn) may contribute to cellular injury. Both WS-PM2.5 and WIS-PM2.5 posed significant cytotoxicity, that WS-PM2.5 was more harmful than WIS-PM2.5 in terms of decreasing cell viability and increasing inflammatory cytokines production. In particular, industrial samples were usually more toxic than urban samples, and those from summer were generally less toxic than other seasons. Hence, in order to mitigate the health risks of PM2.5 pollution, the crucial targets might be components of heavy metals and soluble fractions, and sources in industrial areas, especially during the cold seasons. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=29066 |
| Wei, Y., Chen, Y., Hong, Y., Chen, J., Li, H.-B., Li, H., Yao, X., Mehmood, T., Feng, X., Luo, X.-S. (2024): Comparative in vitro toxicological effects of water-soluble and insoluble components of atmospheric PM2.5 on human lung cells Toxicol. Vitro 98 , art. 105828 10.1016/j.tiv.2024.105828 |
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