Assessing and mapping damage risk of floods for large river basins is still in its infancy. Damage risk is understood to be the combination of flood hazard and the vulnerability of communities to a flood of a particular return period. Risk is calculated and mapped for two communities in which dykes are not located for flood protection: Meissen on the Elbe River and Döbeln in the Mulde catchment. Different methodologies for the computation of flood depth and inundation extent of varying flood return periods (hazard) are compared. Exposure and relative damage to the flooding (vulnerability) based on land-use coverages of different scale are also compared and discussed. A property asset coverage completes the data requirements for the construction of the risk maps. Recommendations for continued research on risk assessments of large river basins conclude the study.