Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1111/j.1365-2222.2006.02576.x
Title (Primary) Association of neuropeptides with Th1/Th2 balance and allergic sensitization in children
Author Herberth, G. ORCID logo ; Dägelmann, C.; Weber, A.; Röder, S. ORCID logo ; Giese, T.; Krämer, U.; Schins, R.P.F.; Behrendt, H.; Borte, M.; Lehmann, I.
Source Titel Clinical and Experimental Allergy
Year 2006
Volume 36
Issue 11
Page From 1408
Page To 1416
Language englisch
Keywords allergic sensitization; children; neuropeptides; somatostatin; substance P; Th1; Th2 balance; vasoactive intestinal peptide
Abstract Background Among neurogenic factors, the neuropeptides have an important regulatory influence on immune system activity and may lead to allergic sensitization.Objective The aim of our study was to investigate the relationship of the neuropeptides vasoactive intestinal peptide (VIP), somatostatin (SOM) and substance P (SP) on modulation of Th1/Th2 balance and allergic sensitization in children.Methods Within the LISAplus (Life style-Immune system-Allergy) study, blood samples of 321 six-year-old children were analysed for concentration of neuropeptides, Th1 and Th2 cytokines, transcription factors for T cell regulation and suppressors of cytokine signalling. In addition, samples were screened for specific IgE against inhalant and food allergens.Results Children with high SOM values showed a Th2 polarization and a reduced expression of FOXP3, the marker for regulatory T cells. High (VIP) levels correlated inversely with the expression of T cell transcription factors (Tbet and SOCS3). In contrast, elevated levels of SP were associated with reduced GATA3 and SOCS3 expression and with increased IFN-? concentrations. Allergic sensitization was more prevalent in children with higher SOM and VIP concentrations but not associated with SP levels.Conclusion Our data reveal an association between neuropeptides and modulatory effects on immune cells in vivo, especially on Th1/Th2 balance with a correlation to allergic sensitization in children. We suggest that elevated SOM and VIP concentrations and the inducing factors should be considered as allergy risk factors.
Persistent UFZ Identifier
Herberth, G., Dägelmann, C., Weber, A., Röder, S., Giese, T., Krämer, U., Schins, R.P.F., Behrendt, H., Borte, M., Lehmann, I. (2006):
Association of neuropeptides with Th1/Th2 balance and allergic sensitization in children
Clin. Exp. Allergy 36 (11), 1408 - 1416 10.1111/j.1365-2222.2006.02576.x