Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1002/ieam.4714 |
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| Title (Primary) | How error-prone bioaccumulation experiments impact the risk assessment of hydrophobic chemicals and what could be improved |
| Author | Glüge, J.; Escher, B.I.; Scheringer, M. |
| Source Titel | Integrated Environmental Assessment and Management |
| Year | 2023 |
| Department | ZELLTOX |
| Volume | 19 |
| Issue | 3 |
| Page From | 792 |
| Page To | 803 |
| Language | englisch |
| Topic | T9 Healthy Planet |
| Supplements | https://setac.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fieam.4714&file=ieam4714-sup-0001-SI1_BCF_Paper.docx https://setac.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fieam.4714&file=ieam4714-sup-0002-SI2_BCFPaper_mitpKa.xlsx |
| Keywords | bioaccumulation; risk assessment; hydrophobic substances; bioconcentration factor |
| Abstract | Bioaccumulation is one of the three criteria for the PBT assessment of chemicals, where P stands for persistence, B for bioaccumulation and T for toxicity, which is a cornerstone for the “Registration, Evaluation, Authorization and Restriction of Chemicals” (REACH) in the EU. REACH requires registrants to submit data on bioaccumulation if the chemical is manufactured in and/or imported to the European Economic Area at more than 100 tonnes per year. Most of the experimental bioaccumulation studies submitted were on the bioconcentration factor (BCF) and were conducted prior to 2012, before the OECD Test Guideline 305 on Bioaccumulation in Fish was updated. An analysis of the submitted data revealed that a lot of the experimental data but also the data from QSARs and other calculation methods underestimate the actual bioaccumulation potential of hydrophobic substances considerably. One of the main reasons in the non-experimental studies is that the BCF is related there to the total concentration of the chemical in water and not to the dissolved chemical concentration. There is therefore an urgent need to re-assess the bioaccumulation potential of the hydrophobic substances registered under REACH. Based on the model calculations in the present study, between 309 and 556 substances that are registered under REACH are likely to bioaccumulate in the aquatic environment – many more than so far identified in the B assessment under REACH. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=26849 |
| Glüge, J., Escher, B.I., Scheringer, M. (2023): How error-prone bioaccumulation experiments impact the risk assessment of hydrophobic chemicals and what could be improved Integr. Environ. Assess. Manag. 19 (3), 792 - 803 10.1002/ieam.4714 |
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