Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1111/j.1365-294X.2008.04057.x
Title (Primary) Long-term survival of a urodele amphibian despite depleted major histocompatibility complex variation
Author Babik, W.; Pabijan, M.; Arntzen, J.W.; Cog─âlniceanu, D.; Durka, W. ORCID logo ; Radwan, J.
Source Titel Molecular Ecology
Year 2009
Department BZF
Volume 18
Issue 5
Page From 769
Page To 781
Language englisch
Keywords amphibian decline; glacial refugia; MHC class II; MHC pseudogenes; positive selection; Triturus cristatus
Abstract Depletion of polymorphism at major histocompatibility complex (MHC) genes has been hypothesized to limit the ability of populations to respond to emerging pathogens, thus putting their survival at risk. As pathogens contribute substantially to the global amphibian decline, assessing patterns of MHC variation is important in devising conservation strategies. Here, we directly compare levels of MHC class II and neutral variation between multiple populations of the great crested newt (Triturus cristatus) from refugial (REF: Romania) and postglacial expansion (PGE: Germany, Poland and UK) areas. REF populations harboured high levels of adaptive variation (24 expressed alleles), exhibiting clear signatures of historical positive selection, which points to the overall importance of MHC class II variation in this species. On the other hand, PGE populations were extremely depauperate (two alleles) but nevertheless have survived for c. 10 000 years, since the postglacial expansion. Variation in putative MHC class II pseudogenes, microsatellites and allozymes also showed a significant southern richness-northern purity pattern. The populations in the postglacial expansion area thus provide the clearest example to date of the long-term survival of populations in which MHC variation, historically under positive selection, has been depleted
Persistent UFZ Identifier
Babik, W., Pabijan, M., Arntzen, J.W., Cog─âlniceanu, D., Durka, W., Radwan, J. (2009):
Long-term survival of a urodele amphibian despite depleted major histocompatibility complex variation
Mol. Ecol. 18 (5), 769 - 781 10.1111/j.1365-294X.2008.04057.x