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Title (Primary) An annotated inventory of Tanzanian medicinal plants traditionally used for the treatment of respiratory bacterial infections
Author Innocent, E.; Marealle, A.I.; Imming, P.; Moeller, L.
Journal Plants
Year 2022
Department UBZ
Volume 11
Issue 7
Page From art. 931
Language englisch
Topic T7 Bioeconomy
Supplements https://www.mdpi.com/article/10.3390/plants11070931/s1
Keywords anti-infective plants; respiratory diseases; natural products; African traditional medicine; Tanzania
Abstract This review comprehensively covers and analyzes scientific information on plants used in Tanzanian traditional medicine against respiratory diseases. It covers ethnobotanical and ethnopharmacological information extracted from SciFinder, Google Scholar, and Reaxys as well as the literature collected at the Institute of Traditional Medicine in Dar-es-Salaam. Crude extracts and fractions of 133 plant species have literature reports on antimicrobial bioassays. Of these, 16 plant species had a minimum inhibitory activity of MIC ≤ 50 µg/mL. Structurally diverse compounds were reported for 49 plant species, of which 7 had constituents with MIC ≤ 5 µg/mL against various bacteria: Bryophyllum pinnatum (Lam.) Oken, Warburgia ugandensis Sprague, Diospyros mespiliformis Hochst. ex DC., Cassia abbreviata Oliv., Entada abyssinica A. Rich., Strychnos spinosa Lam., and Milicia excelsa (Welw.) C.C. Berg. The low number of antimicrobial active extracts and compounds suggests that antibacterial and antimycobacterial drug discovery needs to have a fresh look at ethnobotanical information, diverting from too reductionist an approach and better taking into account that the descriptions of symptoms and concepts of underlying diseases are different in traditional African and modern Western medicine. Nevertheless, some structurally diverse compounds found in anti-infective plants are highlighted in this review as worthy of detailed study and chemical modification.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=25946
Innocent, E., Marealle, A.I., Imming, P., Moeller, L. (2022):
An annotated inventory of Tanzanian medicinal plants traditionally used for the treatment of respiratory bacterial infections
Plants 11 (7), art. 931