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Title (Primary) Extracellular vesicles of mesenchymal stromal cells can be taken up by microglial cells and partially prevent the stimulation induced by β-amyloid
Author Kaniowska, D.; Wenk, K.; Rademacher, P.; Weiss, R.; Fabian, C.; Schulz, I.; Guthardt, M.; Lange, F.; Greiser, S.; Schmidt, M.; Braumann, U.-D.; Emmrich, F.; Koehl, U.; Jaimes, Y.
Journal Stem Cell Reviews and Reports
Year 2022
Department ISOBIO
Volume 18
Issue 3
Page From 1113
Page To 1126
Language englisch
Topic T7 Bioeconomy
Supplements https://static-content.springer.com/esm/art%3A10.1007%2Fs12015-021-10261-4/MediaObjects/12015_2021_10261_MOESM2_ESM.docx
Keywords Neuroinflammation; Amyloid beta; Alzheimer Disease; Microglia; Mesenchymal stromal/stem cells; Extracellular vesicles
Abstract Mesenchymal stromal/stem cells (MSCs) have great capacity for immune regulation. MSCs provide protective paracrine effects, which are partially exerted by extracellular vesicles (EVs). It has been reported that MSCs-derived EVs (MSC-EVs) contain soluble factors, such as cytokines, chemokines, growth factors and even microRNAs, which confer them similar anti-inflammatory and regenerative effects to MSCs. Moreover, MSCs modulate microglia activation through a dual mechanism of action that relies both on cell contact and secreted factors. Microglia cells are the central nervous system immune cells and the main mediators of the inflammation leading to neurodegenerative disorders. Here, we investigated whether MSC-EVs affect the activation of microglia cells by β-amyloid aggregates. We show that the presence of MSC-EVs can prevent the upregulation of pro-inflammatory mediators such as tumor necrosis factor (TNF)-α and nitric oxide (NO). Both are up-regulated in neurodegenerative diseases representing chronic inflammation, as in Alzheimer’s disease. We demonstrate that MSC-EVs are internalized by the microglia cells. Further, our study supports the use of MSC-EVs as a promising therapeutic tool to treat neuroinflammatory diseases.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=25764
Kaniowska, D., Wenk, K., Rademacher, P., Weiss, R., Fabian, C., Schulz, I., Guthardt, M., Lange, F., Greiser, S., Schmidt, M., Braumann, U.-D., Emmrich, F., Koehl, U., Jaimes, Y. (2022):
Extracellular vesicles of mesenchymal stromal cells can be taken up by microglial cells and partially prevent the stimulation induced by β-amyloid
Stem Cell Rev. Rep. 18 (3), 1113 - 1126