Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1007/s12015-021-10261-4 |
| Licence |
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| Title (Primary) | Extracellular vesicles of mesenchymal stromal cells can be taken up by microglial cells and partially prevent the stimulation induced by β-amyloid |
| Author | Kaniowska, D.; Wenk, K.; Rademacher, P.; Weiss, R.; Fabian, C.; Schulz, I.; Guthardt, M.; Lange, F.; Greiser, S.; Schmidt, M.; Braumann, U.-D.; Emmrich, F.; Koehl, U.; Jaimes, Y. |
| Journal | Stem Cell Reviews and Reports |
| Year | 2022 |
| Department | ISOBIO |
| Volume | 18 |
| Issue | 3 |
| Page From | 1113 |
| Page To | 1126 |
| Language | englisch |
| Topic | T7 Bioeconomy |
| Supplements | https://static-content.springer.com/esm/art%3A10.1007%2Fs12015-021-10261-4/MediaObjects/12015_2021_10261_MOESM2_ESM.docx |
| Keywords | Neuroinflammation; Amyloid beta; Alzheimer Disease; Microglia; Mesenchymal stromal/stem cells; Extracellular vesicles |
| UFZ wide themes | ProVIS; |
| Abstract | Mesenchymal stromal/stem cells (MSCs) have great capacity for immune regulation. MSCs provide protective paracrine effects, which are partially exerted by extracellular vesicles (EVs). It has been reported that MSCs-derived EVs (MSC-EVs) contain soluble factors, such as cytokines, chemokines, growth factors and even microRNAs, which confer them similar anti-inflammatory and regenerative effects to MSCs. Moreover, MSCs modulate microglia activation through a dual mechanism of action that relies both on cell contact and secreted factors. Microglia cells are the central nervous system immune cells and the main mediators of the inflammation leading to neurodegenerative disorders. Here, we investigated whether MSC-EVs affect the activation of microglia cells by β-amyloid aggregates. We show that the presence of MSC-EVs can prevent the upregulation of pro-inflammatory mediators such as tumor necrosis factor (TNF)-α and nitric oxide (NO). Both are up-regulated in neurodegenerative diseases representing chronic inflammation, as in Alzheimer’s disease. We demonstrate that MSC-EVs are internalized by the microglia cells. Further, our study supports the use of MSC-EVs as a promising therapeutic tool to treat neuroinflammatory diseases. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=25764 |
| Kaniowska, D., Wenk, K., Rademacher, P., Weiss, R., Fabian, C., Schulz, I., Guthardt, M., Lange, F., Greiser, S., Schmidt, M., Braumann, U.-D., Emmrich, F., Koehl, U., Jaimes, Y. (2022): Extracellular vesicles of mesenchymal stromal cells can be taken up by microglial cells and partially prevent the stimulation induced by β-amyloid Stem Cell Rev. Rep. 18 (3), 1113 - 1126 |
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