Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1186/s12302-022-00592-5 |
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| Title (Primary) | Critical evaluation of the microbial turnover to biomass approach for the estimation of biogenic non-extractable residues (NER) |
| Author | Trapp, S.; Brock, A.L.; Kästner, M.; Schäffer, A.; Hennecke, D. |
| Source Titel | Environmental Sciences Europe |
| Year | 2022 |
| Department | UBT |
| Volume | 34 |
| Page From | art. 15 |
| Language | englisch |
| Topic | T7 Bioeconomy |
| Keywords | persistence assessment; biodegradation; REACH; bound residues |
| Abstract | Persistence is a key criterion for the risk assessment of chemicals. In degradation tests, microbial biodegradation of labeled test chemicals leads to the incorporation of the label in microbial biomass, resulting in biogenic non-extractable residues (bioNER), which are not considered as harmful in persistence assessment. The amount of bioNER can be estimated using the Microbial Turnover to Biomass (MTB) model. MTB estimates the biomass growth during productive degradation of a compound from theoretical growth yield and CO 2 -formation and gives an upper and a lower value for bioNER formation. We collected experimental data in order to test accuracy and precision of this estimation method. In total, 16 experimental studies were found in literature where bioNER was experimentally quantified. Hereof, 13 studies used the amount of label recovered from total amino acid (tAA) content as proxy for bioNER. Unfortunately, the comparison with experimental data was difficult due to the variety of employed methods. A conversion factor is required to extrapolate from tAA on bioNER, and this factor may vary during the experiment and between experiments. The bioNER formation for all compounds tested was calculated with the MTB method, and the outcome was compared to measured tAA as proxy for bioNER. The relation between predicted and measured bioNER was significant, but no better correlation was obtained than with CO 2 to tAA. The mean absolute error of the prediction (low MTB versus tAA) was 5% (unit applied label, %aL). Large deviations between experimentally determined bioNER and the calculated result for some compounds may indicate problems in the experimental determination of bioNER. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=25356 |
| Trapp, S., Brock, A.L., Kästner, M., Schäffer, A., Hennecke, D. (2022): Critical evaluation of the microbial turnover to biomass approach for the estimation of biogenic non-extractable residues (NER) Environ. Sci. Eur. 34 , art. 15 10.1186/s12302-022-00592-5 |
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