Publication Details

Category Text Publication
Reference Category Journals
DOI 10.3390/ijms221910824
Licence creative commons licence
Title (Primary) The role of GPR15 function in blood and vasculature
Author Bauer, M.
Journal International Journal of Molecular Sciences
Year 2021
Department IMMU
Volume 22
Issue 19
Page From art. 10824
Language englisch
Topic T9 Healthy Planet
Keywords GPR15; C10orf99; thrombomodulin; lymphocyte; blood; endothelial cell; vasculature
Abstract Since the first prominent description of the orphan G protein-coupled receptor 15 (GPR15) on lymphocytes as a co-receptor for the human immunodeficiency virus (HIV) type 1 and 2 and the first report about the GPR15-triggered cytoprotective effect on vascular endothelial cells by recombinant human thrombomodulin, several decades passed before the GPR15 has been recently deorphanized. Because of new findings on GPR15, this review will summarize the consequences of GPR15 signaling considering the variety of GPR15-expressing cell types and of GPR15 ligands, with a focus on blood and vasculature.
Persistent UFZ Identifier
Bauer, M. (2021):
The role of GPR15 function in blood and vasculature
Int. J. Mol. Sci. 22 (19), art. 10824