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Title (Primary) Exploiting unconventional prokaryotic hosts for industrial biotechnology
Author Blombach, B.; Gr├╝nberger, A.; Centler, F.; Wierckx, N.; Schmid, J.
Journal Trends in Biotechnology
Year 2022
Department UMB
Volume 40
Issue 4
Page From 385
Page To 397
Language englisch
Topic T7 Bioeconomy
Keywords unconventional production hosts; novel microbial systems; bioprocess development; industrial biotechnology; strain development; Vibrio natriegens; Pseudomonas taiwanensis; Paenibacillus polymyxa; Bacillus methanolicus; metabolic engineering; genetic engineering; alternative carbon sources
Abstract Developing cost-efficient biotechnological processes is a major challenge in replacing fossil-based industrial production processes. The remarkable progress in genetic engineering ensures efficient and fast tailoring of microbial metabolism for a wide range of bioconversions. However, improving intrinsic properties such as tolerance, handling, growth, and substrate consumption rates is still challenging. At the same time, synthetic biology tools are becoming easier applicable and transferable to nonmodel organisms. These trends have resulted in the exploitation of new and unconventional microbial systems with sophisticated properties, which render them promising hosts for the bio-based industry. Here, we highlight the metabolic and cellular capabilities of representative prokaryotic newcomers and discuss the potential and drawbacks of these hosts for industrial application.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=25133
Blombach, B., Gr├╝nberger, A., Centler, F., Wierckx, N., Schmid, J. (2022):
Exploiting unconventional prokaryotic hosts for industrial biotechnology
Trends Biotechnol. 40 (4), 385 - 397