Publication Details

Category Text Publication
Reference Category Journals
DOI 10.3390/biomedicines9080964
Licence creative commons licence
Title (Primary) Non-coding RNA-based biosensors for early detection of liver cancer
Author Falahi, S.; Rafiee-Pour, H.-A.; Zarejousheghani, M.; Rahimi, P.; Joseph, Y.
Source Titel Biomedicines
Year 2021
Department MET
Volume 9
Issue 8
Page From art. 964
Language englisch
Topic T5 Future Landscapes
Keywords liver cancer; non-coding RNAs (ncRNAs); biosensors; electrochemical; optical; electromechanical; nanomaterials
Abstract Primary liver cancer is an aggressive, lethal malignancy that ranks as the fourth leading cause of cancer-related death worldwide. Its 5-year mortality rate is estimated to be more than 95%. This significant low survival rate is due to poor diagnosis, which can be referred to as the lack of sufficient and early-stage detection methods. Many liver cancer-associated non-coding RNAs (ncRNAs) have been extensively examined to serve as promising biomarkers for precise diagnostics, prognostics, and the evaluation of the therapeutic progress. For the simple, rapid, and selective ncRNA detection, various nanomaterial-enhanced biosensors have been developed based on electrochemical, optical, and electromechanical detection methods. This review presents ncRNAs as the potential biomarkers for the early-stage diagnosis of liver cancer. Moreover, a comprehensive overview of recent developments in nanobiosensors for liver cancer-related ncRNA detection is provided.
Persistent UFZ Identifier
Falahi, S., Rafiee-Pour, H.-A., Zarejousheghani, M., Rahimi, P., Joseph, Y. (2021):
Non-coding RNA-based biosensors for early detection of liver cancer
Biomedicines 9 (8), art. 964 10.3390/biomedicines9080964