Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1021/acs.est.1c01836
Document accepted manuscript
Title (Primary) Kinetics of equilibrium passive sampling of organic chemicals with polymers in diverse mammalian tissues
Author Baumer, A.; Jäsch, S.; Ulrich, N.; Bechmann, I.; Landmann, J.; Escher, B.I.
Source Titel Environmental Science & Technology
Year 2021
Department OEC; AUC; ZELLTOX
Volume 55
Issue 13
Page From 9097
Page To 9108
Language englisch
Topic T9 Healthy Planet
Keywords mixture, passive sampling, extraction, biomonitoring, in vitro bioassays
Abstract Equilibrium passive sampling employing polydimethylsiloxane (PDMS) as a sampling phase can be used for the extraction of complex mixtures of organic chemicals from lipid-rich biota. We extended the method to lean tissues and more hydrophilic chemicals by implementing a mass-balance model for partitioning between lipids, proteins, and water in tissues and by accelerating uptake kinetics with a custom-built stirrer that effectively decreased time to equilibrium to less than 8 days even for a homogenized liver tissue with an only 4% lipid content. The partition constants log Klipid/PDMS between tissues and PDMS were derived from measured concentration in PDMS and the mass-balance model and were very similar for 40 neutral chemicals with octanol–water partition constants 1.4 < log Kow < 8.7, that is, log Klipid/PDMS of 1.26 (95% CI, 1.13–1.39) for the adipose tissue, 1.16 (1.00–1.33) for the liver, and 0.58 (0.42–0.73) for the brain. This conversion factor can be applied to interpret chemical analysis and in vitro bioassays after additionally accounting for a small fraction of coextracted lipids of <0.7% of the PDMS weight. PDMS is more widely applicable for passive sampling of mammalian tissues than previously thought, both, in terms of diversity of chemicals and the range of lipid contents of tissues and, therefore, an ideal method for human biomonitoring to be combined with in vitro bioassays.
Persistent UFZ Identifier
Baumer, A., Jäsch, S., Ulrich, N., Bechmann, I., Landmann, J., Escher, B.I. (2021):
Kinetics of equilibrium passive sampling of organic chemicals with polymers in diverse mammalian tissues
Environ. Sci. Technol. 55 (13), 9097 - 9108 10.1021/acs.est.1c01836