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Title (Primary) Structure of chimpanzee gut microbiomes across tropical africa
Author Bueno de Mesquita, C.P.; Nichols, L.M.; Gebert, M.J.; Vanderburgh, C.; Bocksberger, G.; Lester, J.D.; Kalan, A.K.; Dieguez, P.; McCarthy, M.S.; Agbor, A.; Álvarez Varona, P.; Ayimisin, A.E.; Bessone, M.; Chancellor, R.; Cohen, H.; Coupland, C.; Deschner, T.; Egbe, V.E.; Goedmakers, A.; Granjon, A.-C.; Grueter, C.C.; Head, J.; Hernandez-Aguilar, R.A.; Jeffery, K.J.; Jones, S.; Kadam, P.; Kaiser, M.; Lapuente, J.; Larson, B.; Marrocoli, S.; Morgan, D.; Mugerwa, B.; Mulindahabi, F.; Neil, E.; Niyigaba, P.; Piel, A.K.; Robbins, M.M.; Rundus, A.; Sanz, C.M.; Sciaky, L.; Sheil, D.; Sommer, V.; Stewart, F.A.; Ton, E.; van Schijndel, J.; Vergnes, V.; Wessling, E.G.; Wittig, R.M.; Ginath Yuh, Y.; Yurkiw, K.; Zuberbühler, K.; Gogarten, J.F.; Heintz-Buschart, A.; Muellner-Riehl, A.N.; Boesch, C.; Kühl, H.S.; Fierer, N.; Arandjelovic, M.; Dunn, R.R.;
Journal mSystems
Year 2021
Department BOOEK; iDiv;
Volume 6
Issue 3
Language englisch;
Keywords Prokaryotes; Parasites; Diet; Tools; Host genetics; Climate
Abstract

IOUnderstanding variation in host-associated microbial communities is important given the relevance of microbiomes to host physiology and health. Using 560 fecal samples collected from wild chimpanzees (Pan troglodytes) across their range, we assessed how geography, genetics, climate, vegetation, and diet relate to gut microbial community structure (prokaryotes, eukaryotic parasites) at multiple spatial scales. We observed a high degree of regional specificity in the microbiome composition, which was associated with host genetics, available plant foods, and potentially with cultural differences in tool use, which affect diet. Genetic differences drove community composition at large scales, while vegetation and potentially tool use drove within-region differences, likely due to their influence on diet. Unlike industrialized human populations in the United States, where regional differences in the gut microbiome are undetectable, chimpanzee gut microbiomes are far more variable across space, suggesting that technological developments have decoupled humans from their local environments, obscuring regional differences that could have been important during human evolution.

ID 24762
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=24762
Bueno de Mesquita, C.P., Nichols, L.M., Gebert, M.J., Vanderburgh, C., Bocksberger, G., Lester, J.D., Kalan, A.K., Dieguez, P., McCarthy, M.S., Agbor, A., Álvarez Varona, P., Ayimisin, A.E., Bessone, M., Chancellor, R., Cohen, H., Coupland, C., Deschner, T., Egbe, V.E., Goedmakers, A., Granjon, A.-C., Grueter, C.C., Head, J., Hernandez-Aguilar, R.A., Jeffery, K.J., Jones, S., Kadam, P., Kaiser, M., Lapuente, J., Larson, B., Marrocoli, S., Morgan, D., Mugerwa, B., Mulindahabi, F., Neil, E., Niyigaba, P., Piel, A.K., Robbins, M.M., Rundus, A., Sanz, C.M., Sciaky, L., Sheil, D., Sommer, V., Stewart, F.A., Ton, E., van Schijndel, J., Vergnes, V., Wessling, E.G., Wittig, R.M., Ginath Yuh, Y., Yurkiw, K., Zuberbühler, K., Gogarten, J.F., Heintz-Buschart, A., Muellner-Riehl, A.N., Boesch, C., Kühl, H.S., Fierer, N., Arandjelovic, M., Dunn, R.R. (2021):
Structure of chimpanzee gut microbiomes across tropical africa
mSystems 6 (3), e01269-20