Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1021/acs.est.0c03631
Document accepted manuscript
Title (Primary) Abiotic transformation of lamotrigine by redox-active mineral and phenolic compounds
Author Karpov, M.; Seiwert, B.; Mordehay, V.; Reemtsma, T.; Polubesova, T.; Chefetz, B.
Journal Environmental Science & Technology
Year 2021
Department ANA
Volume 55
Issue 3
Page From 1535
Page To 1544
Language englisch
Topic T9 Healthy Planet
Abstract The anticonvulsant drug lamotrigine is a recalcitrant environmental pollutant. It was detected in drinking water, surface water, reclaimed wastewater, arable soils, and even in edible crops. In this work, we studied the mechanisms of lamotrigine transformation by a common redox soil mineral, birnessite, in a single-solute system and in bisolute systems with vanillic acid or o-methoxyphenol. In the single-solute system, 28% of lamotrigine was transformed and 14 transformation products (TPs) were identified. Based on a detailed analysis of the TPs, we suggested that lamotrigine is transformed mainly by oxidation, addition, and dechlorination reactions. In the bisolute systems, the redox-active phenolic compounds enhanced the elimination and transformation of lamotrigine. Vanillic acid was more efficient, generating 92% transformation of lamotrigine (58 TPs were identified), whereas o-methoxyphenol induced 48% transformation (35 TPs were identified). In the bisolute system with phenolic compounds, lamotrigine has possibly been transformed mainly via addition reactions with phenolic compounds and their oxidation products (protocatechuic acid, quinone, and oligomers). Thus, masses of the formed TPs were elevated as compared to the parent compound. The current study demonstrates the important role of redox-active minerals and naturally occurring phenolic compounds in abiotic removal and transformation of a recalcitrant environmental pollutant.
Persistent UFZ Identifier
Karpov, M., Seiwert, B., Mordehay, V., Reemtsma, T., Polubesova, T., Chefetz, B. (2021):
Abiotic transformation of lamotrigine by redox-active mineral and phenolic compounds
Environ. Sci. Technol. 55 (3), 1535 - 1544