Publication Details

Category Text Publication
Reference Category Book chapters
DOI 10.1016/B978-0-12-818508-7.00006-3
Title (Primary) To B (e) born: New concepts concerning B cells throughout pregnancy
Title (Secondary) Reproductive immunology: Basic concepts
Author Busse, M.; Schumacher, A.; Zenclussen, A.C.
Publisher Mor, G.
Year 2021
Department IMMU
Page From 73
Page To 90
Language englisch
Topic T9 Healthy Planet
Keywords B cells; Fetal tolerance; Pregnancy; Preterm birth; Uterus
Abstract A complex interplay between immune cells, the molecules they secrete, the cells they interact with, and hormones is crucial for pregnancy establishment and maintenance. Small perturbances of this finely modulated and timely defined balance can have serious consequences for both mother and fetus. In this chapter, we revise data regarding B cells and their importance for gestation. The study of this particular cell type during pregnancy has long been neglected. B cells represent an extremely complex cell population as they can present antigen, interact with other immune cells, secrete cytokines, and antibodies. Most recent data show their plasticity and the pivotal role they play in sustaining pregnancy and as regulators of the balance between tolerance and immunity.
Persistent UFZ Identifier
Busse, M., Schumacher, A., Zenclussen, A.C. (2021):
To B (e) born: New concepts concerning B cells throughout pregnancy
In: Mor, G. (ed.)
Reproductive immunology: Basic concepts
Academic Press / Elsevier, London, p. 73 - 90 10.1016/B978-0-12-818508-7.00006-3