Publication Details

Reference Category Book chapters
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Title (Primary) To B (e) born: New concepts concerning B cells throughout pregnancy
Title (Secondary) Reproductive immunology: Basic concepts
Author Busse, M.; Schumacher, A.; Zenclussen, A.C.;
Year 2021
Department IMMU;
Keywords B cells; Fetal tolerance; Pregnancy; Preterm birth; Uterus
Abstract A complex interplay between immune cells, the molecules they secrete, the cells they interact with, and hormones is crucial for pregnancy establishment and maintenance. Small perturbances of this finely modulated and timely defined balance can have serious consequences for both mother and fetus. In this chapter, we revise data regarding B cells and their importance for gestation. The study of this particular cell type during pregnancy has long been neglected. B cells represent an extremely complex cell population as they can present antigen, interact with other immune cells, secrete cytokines, and antibodies. Most recent data show their plasticity and the pivotal role they play in sustaining pregnancy and as regulators of the balance between tolerance and immunity.
ID 24322
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=24322
Busse, M., Schumacher, A., Zenclussen, A.C. (2021):
To B (e) born: New concepts concerning B cells throughout pregnancy
Reproductive immunology: Basic concepts
Academic Press / Elsevier, London, p. 73 - 90