Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1002/etc.4954
Licence creative commons licence
Title (Primary) Estimating the equilibrium distribution of perfluoroalkyl acids (PFAAs) and four of their alternatives in mammals
Author Allendorf, F.; Goss, K.-U.; Ulrich, N.
Source Titel Environmental Toxicology and Chemistry
Year 2021
Department AUC
Volume 40
Issue 3
Page From 910
Page To 920
Language englisch
Topic T9 Healthy Planet
Keywords accumulation of PFAAs and alternatives; structural proteins/water distribution coefficients; storage lipids/water distribution coefficients; organ/water distribution coefficients; predicting tissue distribution of PFAAs; physiologically based distribution

Perfluoroalkyl acids (PFAAs) are the first mostly ionic compounds that are of major concern due to their accumulative behavior. The discussion about their risk is ongoing considering the increasing production of structurally similar alternatives.

Here we conducted model calculations based on equilibrium distribution coefficients that allow studying the distribution of PFAAs and their alternatives in various mammalian organs through comparison to empirical measurements in humans and rats. The calculations rely on experimentally determined distribution coefficients of a series of PFAAs and four of their alternatives to physiological matrices such as structural proteins, storage lipids, membrane lipids, albumin, and fatty acid binding protein (FABP). The relative sorption capacities in each organ were calculated from the combination of distribution coefficients and physiological data. The calculated distribution of PFAAs and alternatives within the organs showed that albumin and membrane lipids and to a lesser extent also structural proteins have the highest relative sorption capacities for the compounds. Sorption to FABP is only relevant in the distribution of short‐chain PFAAs. Storage lipids play a minor role for the distribution of all studied compounds. Our calculated distribution of PFAAs was evaluated by comparison to reported PFAA concentrations in various organs.

Persistent UFZ Identifier
Allendorf, F., Goss, K.-U., Ulrich, N. (2021):
Estimating the equilibrium distribution of perfluoroalkyl acids (PFAAs) and four of their alternatives in mammals
Environ. Toxicol. Chem. 40 (3), 910 - 920 10.1002/etc.4954