Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1073/pnas.2001063117
Licence creative commons licence
Title (Primary) The Great Oxidation Event expanded the genetic repertoire of arsenic metabolism and cycling
Author Chen, S.-C.; Sun, G.-X.; Yan, Y.; Konstantinidis, K.T.; Zhang, S.-Y.; Deng, Y.; Li, X.-M.; Cui, H.-L.; Musat, F.; Popp, D.; Rosen, B.P.; Zhu, Y.-G.
Source Titel Proceedings of the National Academy of Sciences of the United States of America
Year 2020
Department ISOBIO; UMB
Volume 117
Issue 19
Page From 10414
Page To 10421
Language englisch
Keywords arsenic; detoxification; evolution; oxygen; biogeochemistry
Abstract The rise of oxygen on the early Earth about 2.4 billion years ago reorganized the redox cycle of harmful metal(loids), including that of arsenic, which doubtlessly imposed substantial barriers to the physiology and diversification of life. Evaluating the adaptive biological responses to these environmental challenges is inherently difficult because of the paucity of fossil records. Here we applied molecular clock analyses to 13 gene families participating in principal pathways of arsenic resistance and cycling, to explore the nature of early arsenic biogeocycles and decipher feedbacks associated with planetary oxygenation. Our results reveal the advent of nascent arsenic resistance systems under the anoxic environment predating the Great Oxidation Event (GOE), with the primary function of detoxifying reduced arsenic compounds that were abundant in Archean environments. To cope with the increased toxicity of oxidized arsenic species that occurred as oxygen built up in Earth’s atmosphere, we found that parts of preexisting detoxification systems for trivalent arsenicals were merged with newly emerged pathways that originated via convergent evolution. Further expansion of arsenic resistance systems was made feasible by incorporation of oxygen-dependent enzymatic pathways into the detoxification network. These genetic innovations, together with adaptive responses to other redox-sensitive metals, provided organisms with novel mechanisms for adaption to changes in global biogeocycles that emerged as a consequence of the GOE.
Persistent UFZ Identifier
Chen, S.-C., Sun, G.-X., Yan, Y., Konstantinidis, K.T., Zhang, S.-Y., Deng, Y., Li, X.-M., Cui, H.-L., Musat, F., Popp, D., Rosen, B.P., Zhu, Y.-G. (2020):
The Great Oxidation Event expanded the genetic repertoire of arsenic metabolism and cycling
Proc. Natl. Acad. Sci. U.S.A. 117 (19), 10414 - 10421 10.1073/pnas.2001063117