Publication Details

Category Text Publication
Reference Category Journals
DOI 10.3389/fmicb.2020.00143
Licence creative commons licence
Title (Primary) Explorative meta-analysis of 377 extant fungal genomes predicted a total mycobiome functionality of 42.4 million KEGG functions
Author Starke, R.; Capek, P.; Morais, D.; Jehmlich, N. ORCID logo ; Baldrian, P.
Source Titel Frontiers in Microbiology
Year 2020
Department MOLSYB
Volume 11
Page From art. 143
Language englisch
Supplements https://ndownloader.figshare.com/files/21593016
Keywords functional diversity, fungi, microbiome, accumulation curves, modeling
Abstract Unveiling the relationship between taxonomy and function of the microbiome is crucial to determine its contribution to ecosystem functioning. However, while there is a considerable amount of information on microbial taxonomic diversity, our understanding of its relationship to functional diversity is still scarce. Here, we used a meta-analysis of completely annotated extant genomes of 377 taxonomically distinct fungal species to predict the total fungal microbiome functionality on Earth with accumulation curves (ACs) of all known functions from the level 3 of KEGG Orthology using both parametric and non-parametric estimates in an explorative data-mining approach. The unsaturated model extrapolating functional diversity as a function of species richness described the ACs significantly better than the saturated model that assumed a limited total number of functions, which suggested the presence of widespread and rare functions. Based on previous estimates of 3.8 million fungal species on Earth, we propagated the unsaturated model to predict a total of 42.4 ± 0.5 million KEGG level 3 functions of which only 0.06% are known today. Our approach not only highlights the presence of widespread and rare functions but points toward the necessity of novel and more sophisticated methods to unveil the entirety of functions to fully understand the involvement of the fungal microbiome in ecosystem functioning.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=22930
Starke, R., Capek, P., Morais, D., Jehmlich, N., Baldrian, P. (2020):
Explorative meta-analysis of 377 extant fungal genomes predicted a total mycobiome functionality of 42.4 million KEGG functions
Front. Microbiol. 11 , art. 143