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Title (Primary) Regulatory systems for gene expression control in cyanobacteria
Author Till, P.; Toepel, J.; Bühler, B.; Mach, R.L.; Mach-Aigner, A.R.
Journal Applied Microbiology and Biotechnology
Year 2020
Department SOMA
Volume 104
Issue 5
Page From 1977
Page To 1991
Language englisch
Keywords Cyanobacteria; Geneexpression; Induction systems; Promoters; Riboswitches; Riboregulators; Regulatory circuits
Abstract As photosynthetic microbes, cyanobacteria are attractive hosts for the production of high-value molecules from CO2 and light. Strategies for genetic engineering and tightly controlled gene expression are essential for the biotechnological application of these organisms. Numerous heterologous or native promoter systems were used for constitutive and inducible expression, yet many of them suffer either from leakiness or from a low expression output. Anyway, in recent years, existing systems have been improved and new promoters have been discovered or engineered for cyanobacteria. Moreover, alternative tools and strategies for expression control such as riboswitches, riboregulators or genetic circuits have been developed. In this mini-review, we provide a broad overview on the different tools and approaches for the regulation of gene expression in cyanobacteria and explain their advantages and disadvantages.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=22740
Till, P., Toepel, J., Bühler, B., Mach, R.L., Mach-Aigner, A.R. (2020):
Regulatory systems for gene expression control in cyanobacteria
Appl. Microbiol. Biotechnol. 104 (5), 1977 - 1991