Publication Details

Reference Category Journals
DOI / URL link
Title (Primary) Towards a consistent, quantitative evaluation of microRNA evolution
Author Yazbeck, A.M.; Tout, K.R.; Stadler, P.F.; Hertel, J.;
Journal Journal of Integrative Bioinformatics
Year 2017
Department MOLSYB;
Volume 14
Issue 1
Language englisch;
POF III (all) F11;
Keywords Alignments; Homology Search; miRBase; ascertainment biases
Abstract

The miRBase currently reports more than 25,000 microRNAs in several hundred genomes that belong to more than 1000 families of homologous sequences. Quantitative investigations of miRNA gene evolution requires the construction of data sets that are consistent in their coverage and include those genomes that are of interest in a given study. Given the size and structure of data, this can be achieved only with the help of a fully automatic pipeline that improves the available seed alignments, extends the set of available sequences by homology search, and reliably identifies true positive homology search results. Here we describe the current progress towards such a system, emphasizing the task of improving and completing the initial seed alignment.

ID 21392
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=21392
Yazbeck, A.M., Tout, K.R., Stadler, P.F., Hertel, J. (2017):
Towards a consistent, quantitative evaluation of microRNA evolution
J. Integr. Bioinform. 14 (1)