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Title (Primary) In situ O2 generation for biocatalytic oxyfunctionalization reactions
Author Hoschek, A.; Schmid, A.; Bühler, B.;
Journal ChemCatChem
Year 2018
Department SOMA;
Volume 10
Issue 23
Language englisch;
POF III (all) R61;
Keywords Biocatalysis; Oxyfunctionalization; Oxygen mass transfer; Photosynthesis; Water oxidation
Abstract O2‐dependent whole‐cell bioprocesses, such as C−H oxyfunctionalizations, are constrained by technically limited O2 mass transfer and biocatalyst‐inherent O2 respiration. In large‐scale bioprocesses, this restricts the maximum achievable productivity to 5.6 gproduct L−1 h−1 assuming a resting cell concentration of 9.4 gCDW L−1. This concept paper discusses strategies to enhance the O2 availability for biocatalytic oxyfunctionalizations with a focus on the in situ generation of O2 from water. This promising approach was addressed recently by the exploitation of microbial photosynthesis for light‐driven C−H oxyfunctionalization. Via intracellular O2 evolution, phototrophic biocatalysts increase the maximum achievable productivity well beyond technical boundaries. This fundamental advantage over O2‐respiring biocatalysts now awaits scale‐up evaluations, combining established cultivation technologies for phototrophic organisms with bioprocessing techniques for heterotrophic organisms.
ID 21083
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Hoschek, A., Schmid, A., Bühler, B. (2018):
In situ O2 generation for biocatalytic oxyfunctionalization reactions
ChemCatChem 10 (23), 5366 - 5371