Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/j.coesh.2018.06.006
Document accepted manuscript
Title (Primary) In vitro bioassays to assess drinking water quality
Author Neale, P.A.; Escher, B.I.
Source Titel Current Opinion in Environmental Science & Health
Year 2019
Department ZELLTOX
Volume 7
Page From 1
Page To 7
Language englisch
Keywords Bioanalysis; Drinking water treatment Effect-based trigger value; Estrogenic activity; Iceberg modelling; Reactive toxicity
Abstract In vitro assays indicative of different stages of cellular toxicity pathways have been applied to both source water and drinking water. The majority of studies showed a decrease in receptor-mediated effects after drinking water treatment due to the removal of micropollutants, while reactive toxicity typically increased after chlorination due to the formation of disinfection by-products. Using both chemical analysis and bioanalysis, iceberg modelling can be applied to determine which chemicals are contributing to the observed effect, though one limitation is that typical sample pretreatment for bioanalysis fails to capture volatile chemicals. Bioassays are increasingly sensitive and effects can be detected in clean samples, thus effect-based trigger values can be applied to determine whether an effect in drinking water is acceptable.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=20812
Neale, P.A., Escher, B.I. (2019):
In vitro bioassays to assess drinking water quality
Curr. Opin. Environ. Sci. Health 7 , 1 - 7 10.1016/j.coesh.2018.06.006