Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1016/j.chemosphere.2018.02.026
Document author version
Title (Primary) Equilibrium biopartitioning of organic anions - A case study for humans and fish
Author Goss, K.-U.; Bittermann, K.; Henneberger, L.; Linden, L.
Source Titel Chemosphere
Year 2018
Department AUC; ZELLTOX
Volume 199
Page From 174
Page To 181
Language englisch
Supplements https://ars.els-cdn.com/content/image/1-s2.0-S0045653518302261-mmc1.docx
Keywords Bioaccumulation; Organic anions; Partitioning; Bioconcentration; Risk assessment; Chemical regulation
UFZ wide themes RU3;
Abstract In this work we combine partition coefficients between water and membrane lipid, storage lipid, the plasma protein albumin as well as structural protein with the tissue dependent fraction of the respective phases in order to obtain a clearer picture on the relevance of various biological tissues for the bioaccumulation of 31 organic anions. Most of the partition coefficients are based on experimental data, supplemented by some predicted ones. The data suggest that the plasma protein, albumin, will be the major sorption matrix in mammals. Only small fractions of the studied chemicals will occur freely dissolved in an organism. For the investigated acids with pKa <5, partitioning is dominated by the ionic species rather than the corresponding neutral species. Bioconcentration in fish is not expected to occur for many of these acids unless pH in the aqueous environment is low or specific sorption mechanisms are relevant. In contrast, biomagnification in terrestrial mammals would be expected for most organic anions if they are not sufficiently metabolized. We conclude that sorption is important for the toxicokinetics of ionizable organic chemicals and the dominating sorbing matrices are quite different from those for neutral species.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19897
Goss, K.-U., Bittermann, K., Henneberger, L., Linden, L. (2018):
Equilibrium biopartitioning of organic anions - A case study for humans and fish
Chemosphere 199 , 174 - 181 10.1016/j.chemosphere.2018.02.026