Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1007/s00204-017-2117-4
Document Shareable Link
Title (Primary) Desorption kinetics of organic chemicals from albumin
Author Krause, S.; Ulrich, N.; Goss, K.-U.
Source Titel Archives of Toxicology
Year 2018
Department AUC
Volume 92
Issue 3
Page From 1065
Page To 1074
Language englisch
Keywords Albumin; Desorption kinetics; Protein-binding
UFZ wide themes RU3;
Abstract When present in blood, most chemicals tend to bind to the plasma protein albumin. For distribution into surrounding tissues, desorption from albumin is necessary, because only the unbound form of a chemical is assumed to be able to cross cell membranes. For metabolism of chemicals, the liver is a particularly important organ. One potentially limiting step for hepatic uptake of the chemicals is desorption from albumin, because blood passes the human liver within seconds. Desorption kinetics from albumin can thus be an important parameter for our pharmacokinetic and toxicokinetic understanding of chemicals. This work presents a dataset of measured desorption rate constants and reveals a possibility for their prediction. Additionally, the obtained extraction profiles directly indicate physiological relevance of desorption kinetics, because desorption of the test chemicals is still incomplete after time frames comparable to the residence time of blood in the liver.
Persistent UFZ Identifier
Krause, S., Ulrich, N., Goss, K.-U. (2018):
Desorption kinetics of organic chemicals from albumin
Arch. Toxicol. 92 (3), 1065 - 1074 10.1007/s00204-017-2117-4