Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1093/femsre/fux044
Title (Primary) Beyond the bulk: disclosing the life of single microbial cells
Author Rosenthal, K.; Oehling, V.; Dusny, C.; Schmid, A.
Source Titel FEMS Microbiology Reviews
Year 2017
Department SOMA
Volume 41
Issue 6
Page From 751
Page To 780
Language englisch
Keywords single cell analysis; heterogeneity; single cell dynamics; microfluidics; technical bias; lab-on-a-chip
UFZ wide themes RU4;
Abstract Microbial single cell analysis has led to discoveries that are beyond what can be resolved with population-based studies. It provides a pristine view of the mechanisms that organize cellular physiology, unbiased by population heterogeneity or uncontrollable environmental impacts. A holistic description of cellular functions at the single cell level requires analytical concepts beyond the miniaturization of existing technologies, defined but uncontrolled by the biological system itself. This review provides an overview of the latest advances in single cell technologies and demonstrates their potential. Opportunities and limitations of single cell microbiology are discussed using selected application-related examples.
Persistent UFZ Identifier
Rosenthal, K., Oehling, V., Dusny, C., Schmid, A. (2017):
Beyond the bulk: disclosing the life of single microbial cells
FEMS Microbiol. Rev. 41 (6), 751 - 780 10.1093/femsre/fux044