Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1093/femsre/fux044 |
| Title (Primary) | Beyond the bulk: disclosing the life of single microbial cells |
| Author | Rosenthal, K.; Oehling, V.; Dusny, C.; Schmid, A. |
| Source Titel | FEMS Microbiology Reviews |
| Year | 2017 |
| Department | SOMA |
| Volume | 41 |
| Issue | 6 |
| Page From | 751 |
| Page To | 780 |
| Language | englisch |
| Keywords | single cell analysis; heterogeneity; single cell dynamics; microfluidics; technical bias; lab-on-a-chip |
| UFZ wide themes | RU4; |
| Abstract | Microbial single cell analysis has led to discoveries that are beyond what can be resolved with population-based studies. It provides a pristine view of the mechanisms that organize cellular physiology, unbiased by population heterogeneity or uncontrollable environmental impacts. A holistic description of cellular functions at the single cell level requires analytical concepts beyond the miniaturization of existing technologies, defined but uncontrolled by the biological system itself. This review provides an overview of the latest advances in single cell technologies and demonstrates their potential. Opportunities and limitations of single cell microbiology are discussed using selected application-related examples. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=19441 |
| Rosenthal, K., Oehling, V., Dusny, C., Schmid, A. (2017): Beyond the bulk: disclosing the life of single microbial cells FEMS Microbiol. Rev. 41 (6), 751 - 780 10.1093/femsre/fux044 |
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