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Title (Primary) Uptake kinetics and subcellular compartmentalization explain lethal but not sublethal effects of cadmium in two closely related amphipod species
Author Jakob, L.; Bedulina, D.S.; Axenov-Gribanov, D.V.; Ginzburg, M.; Shatilina, Z.M.; Lubyaga, Y.A.; Madyarova, E.V.; Gurkov, A.N.; Timofeyev, M.A.; Portner, H.-O.; Sartoris, F.J.; Altenburger, R.; Luckenbach, T.;
Journal Environmental Science & Technology
Year 2017
Department BIOTOX;
Volume 51
Issue 12
Language englisch;
POF III (all) T32;
UFZ wide themes RU2;
Abstract Eulimnogammarus cyaneus and Eulimnogammarus verrucosus, closely related amphipod species endemic to Lake Baikal, differ with respect to body size (10- to 50-fold lower fresh weights of E. cyaneus) and cellular stress response (CSR) capacity, potentially causing species-related differences in uptake, internal sequestration, and toxic sensitivity to waterborne cadmium (Cd). We found that, compared to E. verrucosus, Cd uptake rates, related to a given exposure concentration, were higher, and lethal concentrations (50%; LC50) were 2.3-fold lower in E. cyaneus (4 weeks exposure; 6 °C). Upon exposures to species-specific subacutely toxic Cd concentrations (nominal LC1; E. cyaneus: 18 nM (2.0 μg L–1); E. verrucosus: 115 nM (12.9 μg L–1); 4 weeks exposure; 6 °C), Cd amounts in metal sensitive tissue fractions (MSF), in relation to fresh weight, were similar in both species (E. cyaneus: 0.25 ± 0.06 μg g–1; E. verrucosus: 0.26 ± 0.07 μg g–1), whereas relative Cd amounts in the biologically detoxified heat stable protein fraction were 35% higher in E. cyaneus. Despite different potencies in detoxifying Cd, body size appears to mainly explain species-related differences in Cd uptake and sensitivities. When exposed to Cd at LC1 over 4 weeks, only E. verrucosus continuously showed 15-36% reduced oxygen consumption rates indicating metabolic depression and pointing to particular sensitivity of E. verrucosus to persisting low-level toxicant pressure.
ID 18722
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=18722
Jakob, L., Bedulina, D.S., Axenov-Gribanov, D.V., Ginzburg, M., Shatilina, Z.M., Lubyaga, Y.A., Madyarova, E.V., Gurkov, A.N., Timofeyev, M.A., Portner, H.-O., Sartoris, F.J., Altenburger, R., Luckenbach, T. (2017):
Uptake kinetics and subcellular compartmentalization explain lethal but not sublethal effects of cadmium in two closely related amphipod species
Environ. Sci. Technol. 51 (12), 7208 - 7218