Publication Details

Category Text Publication
Reference Category Journals
DOI 10.1002/etc.3680
Title (Primary) Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities
Author Armitage, J.M.; Erickson, R.J.; Luckenbach, T. ORCID logo ; Ng, C.A.; Prosser, R.S.; Arnot, J.A.; Schirmer, K.; Nichols, J.W.
Source Titel Environmental Toxicology and Chemistry
Year 2017
Department BIOTOX
Volume 36
Issue 4
Page From 882
Page To 897
Language englisch
Keywords Bioaccumulation; Toxicokinetics; Ecological risk assessment; Ionizable organic chemicals
UFZ wide themes RU3;
Abstract The objective of the present study is to review current knowledge regarding the bioaccumulation potential of IOCs, with a focus on the availability of empirical data for fish. Aspects of the bioaccumulation potential of IOCs in fish that can be characterized relatively well include the pH-dependence of gill uptake and elimination, uptake in the gut, and sorption to phospholipids (membrane-water partitioning). Key challenges include the lack of empirical data for biotransformation and binding in plasma. Fish possess a diverse array of proteins which may transport IOCs across cell membranes. Except in a few cases, however, the significance of this transport for uptake and accumulation of environmental contaminants is unknown. Two case studies are presented. The first describes modeled effects of pH and biotransformation on bioconcentration of organic acids and bases, while the second employs an updated model to investigate factors responsible for accumulation of perfluoroalkylated acids (PFAA). The PFAA case study is notable insofar as it illustrates the likely importance of membrane transporters in the kidney and highlights the potential value of read across approaches. Recognizing the current need to perform bioaccumulation hazard assessments and ecological and exposure risk assessment for IOCs, we provide a tiered strategy that progresses (as needed) from conservative assumptions (models and associated data) to more sophisticated models requiring chemical-specific information.
Persistent UFZ Identifier
Armitage, J.M., Erickson, R.J., Luckenbach, T., Ng, C.A., Prosser, R.S., Arnot, J.A., Schirmer, K., Nichols, J.W. (2017):
Assessing the bioaccumulation potential of ionizable organic compounds: Current knowledge and research priorities
Environ. Toxicol. Chem. 36 (4), 882 - 897 10.1002/etc.3680