Publication Details
Category Text Publication
Reference Category Book chapters
DOI 10.1016/bs.coac.2016.01.010
Title (Primary) High-resolution mass spectrometry in the effect-directed analysis of water resources
Title (Secondary) Applications of time-of-flight and orbitrap mass spectrometry in environmental, food, doping, and forensic analysis
Author Krauss, M. ORCID logo
Publisher Pérez, S.; Eichhorn, P.; Barceló, D.
Source Titel Comprehensive Analytical Chemistry
Year 2016
Department WANA
Volume 71
Page From 433
Page To 457
Language englisch
UFZ wide themes RU2;
Abstract Effect-directed analysis (EDA) is an approach to identify chemicals in complex mixtures which exert adverse effects. To this end, a combination of bioassays for effect detection, fractionation to reduce sample complexity, and chemical analysis mainly by liquid or gas chromatography coupled to mass spectrometry is used. High-resolution mass spectrometry (HRMS) using orbitrap or time-of-flight analysers has become a key technique for EDA, as it allows for an equally sensitive and selective analysis of samples without a pre-definition of the compounds of interest. This chapter provides an overview on the state of the art of HRMS in EDA studies on water and sediment. The main HRMS-based strategies such as target screening, screening for suspected toxicants, library search, and true unknown identification are presented, highlighting the way these were used in different studies including their strengths and current limitations.
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17574
Krauss, M. (2016):
High-resolution mass spectrometry in the effect-directed analysis of water resources
In: Pérez, S., Eichhorn, P., Barceló, D. (eds.)
Applications of time-of-flight and orbitrap mass spectrometry in environmental, food, doping, and forensic analysis
Comprehensive Analytical Chemistry 71
Elsevier, Amsterdam, p. 433 - 457 10.1016/bs.coac.2016.01.010