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Title (Primary) Time-dependent effects in algae for chemicals with different adverse outcome pathways: a novel approach
Author Vogs, C.; Altenburger, R.;
Journal Environmental Science & Technology
Year 2016
Department BIOTOX;
Volume 50
Issue 14
Language englisch;
POF III (all) T42;
UFZ wide themes RU3;
Abstract Chemicals affect unicellular algae as a result of toxicokinetic and toxicodynamic processes. The internal concentration of chemicals in algae cells typically reaches equilibrium within minutes, while damage cumulatively increases over hours. That time-gap between steady-state of internal exposure and damage development is thus suspected to span up to hours mainly due to toxicodynamic processes. The quantification of rate-limited toxicodynamic processes, aggregated as progressed effect from an initiating molecular event through biological key events towards the adverse outcome on algae growth inhibition, might discriminate between different adverse outcome pathways (AOPs). To support our hypothesis, six chemicals were selected according to different physicochemical properties and three distinctly dissimilar AOPs. The time-courses of internal concentrations were linked to the observed affected Scenedesmus vacuolatus growth using toxicokinetic-toxicodynamic modeling. Effects on cell growth were explained by effect progression rather than the times until internal equilibrium concentrations were reached. Effect progression rates ranged over six orders of magnitude for all chemicals, but amounted to less than one order of magnitude within similar AOP: photosystem II inhibitors > reactive chemicals > lipid biosynthesis inhibitors meaning that inhibitors of photosystem II progress an effect towards algae growth fastest compared to reactive chemicals and inhibitors of lipid biosynthesis.
ID 17483
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17483
Vogs, C., Altenburger, R. (2016):
Time-dependent effects in algae for chemicals with different adverse outcome pathways: a novel approach
Environ. Sci. Technol. 50 (14), 7770 - 7780