Publication Details |
| Category | Text Publication |
| Reference Category | Journals |
| DOI | 10.1021/acs.est.6b00529 |
| Title (Primary) | Time-dependent effects in algae for chemicals with different adverse outcome pathways: a novel approach |
| Author | Vogs, C.; Altenburger, R.
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| Source Titel | Environmental Science & Technology |
| Year | 2016 |
| Department | BIOTOX |
| Volume | 50 |
| Issue | 14 |
| Page From | 7770 |
| Page To | 7780 |
| Language | englisch |
| UFZ wide themes | RU3; |
| Abstract | Chemicals affect unicellular algae as a result of toxicokinetic and toxicodynamic processes. The internal concentration of chemicals in algae cells typically reaches equilibrium within minutes, while damage cumulatively increases over hours. That time-gap between steady-state of internal exposure and damage development is thus suspected to span up to hours mainly due to toxicodynamic processes. The quantification of rate-limited toxicodynamic processes, aggregated as progressed effect from an initiating molecular event through biological key events towards the adverse outcome on algae growth inhibition, might discriminate between different adverse outcome pathways (AOPs). To support our hypothesis, six chemicals were selected according to different physicochemical properties and three distinctly dissimilar AOPs. The time-courses of internal concentrations were linked to the observed affected Scenedesmus vacuolatus growth using toxicokinetic-toxicodynamic modeling. Effects on cell growth were explained by effect progression rather than the times until internal equilibrium concentrations were reached. Effect progression rates ranged over six orders of magnitude for all chemicals, but amounted to less than one order of magnitude within similar AOP: photosystem II inhibitors > reactive chemicals > lipid biosynthesis inhibitors meaning that inhibitors of photosystem II progress an effect towards algae growth fastest compared to reactive chemicals and inhibitors of lipid biosynthesis. |
| Persistent UFZ Identifier | https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17483 |
| Vogs, C., Altenburger, R. (2016): Time-dependent effects in algae for chemicals with different adverse outcome pathways: a novel approach Environ. Sci. Technol. 50 (14), 7770 - 7780 10.1021/acs.est.6b00529 |
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