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Title (Primary) Functional micelles formed by branched polymeric surfactants: synthesis, characteristics, and application as nanoreactors and carriers
Author Riabtseva, A.; Mitina, N.; Grytsyna, I.; Boiko, N.; Garamus, V.M.; Stryhanyuk, H.; Stoika, R.; Zaichenko, A.;
Journal European Polymer Journal
Year 2016
Department ISOBIO;
Volume 75
Language englisch;
POF III (all) T41;
Keywords Branched polymer; Micelles; Carriers; Maghemite particles; Tumor cells; Engulfment
UFZ wide themes RU3;
Abstract Branched polymeric surfactants composed of grafted non-ionic polyethylene glycol (PEG) and anionic polyelectrolyte chains were synthesized via radical polymerization initiated by the comb-like PEG-containing polyperoxide. Above definite concentration in solution, these surfactants form micelle-like structures (MLS). The MLS formed by branched polymeric molecules are of larger size in comparison with size of MLS formed by the initial PEG-containing polyperoxide that is caused mainly by different mechanism of their self-organization and morphology of formed MLS. The availability of grafted polyelectrolyte chains in the MLS provides a possibility of their use as the containers for immobilization of bio-active substances and nucleation of the inorganic nanoparticles, as well as formation of their stable colloidal systems in water in a wide pH range. Noticeable compaction and narrowed size distribution of the MLS were revealed after immobilization of doxorubicin (Dox) molecules or Fe2O3 nanocrystals. MLS-based systems were used for delivery of Dox and maghemite particles at treatment of tumor cells. Both MLS-based formulations of Dox and Fe2O3 were efficiently engulfed by rat glioma C6 cells. A significant (10 times) decrease in the effective therapeutic dose of Dox was found when this drug was delivered by a MLS-based formulation of Dox. That effect might be explained by a specific structure and functionality of the novel carrier used for immobilization of drug that should be delivered to target cells.
ID 17200
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=17200
Riabtseva, A., Mitina, N., Grytsyna, I., Boiko, N., Garamus, V.M., Stryhanyuk, H., Stoika, R., Zaichenko, A. (2016):
Functional micelles formed by branched polymeric surfactants: synthesis, characteristics, and application as nanoreactors and carriers
Eur. Polym. J. 75 , 406 - 422