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Title (Primary) Multidimensional isotope analysis of carbon, hydrogen and oxygen as tool for identification of the origin of ibuprofen
Author Gilevska, T.; Gehre, M.; Richnow, H.H.;
Journal Journal of Pharmaceutical and Biomedical Analysis
Year 2015
Department ISOBIO;
Volume 115
Language englisch;
POF III (all) T41;
Keywords Ibuprofen; Synthetic pathway; Isotope ratios; δ13C; δ18O; δ2H; IRMS; Drug counterfeiting
UFZ wide themes RU3;
Abstract Multidimensional isotope profiling is a useful tool for the characterization of the provenance of active pharmaceutical ingredients (API). To evaluate this approach, samples of the nonsteroidal anti-inflammatory drug (NSAIDs) ibuprofen were collected from 32 manufactures and 13 countries, and carbon, hydrogen and oxygen isotope ratios were analyzed by elemental analyzer, chromium-filled elemental analyzer and high temperature conversion elemental analyzer (EA, Cr-EA and TC/EA) coupled to an isotope ratio mass spectrometry (IRMS). The range of isotope values of ibuprofen (δ13C: −33.2 ± 0.1‰ to −27.4 ± 0.1‰; δ2H: −121.4 ± 1.5‰ to −41.2 ± 0.8‰; and δ18O: −12.6 ± 0.3‰ to 19.0 ± 0.6‰) allowed characterization and distinction of 5 groups, which reflect synthetic pathways and/or use of different raw materials, as well as possible isotope fractionation during the synthesis reactions. This study highlights that multi isotope fingerprinting has potential for identification of sources, and provides a database of isotope composition of ibuprofen (δ2H, δ13C, δ18O) that might improve the tracing of origin, transport pathways and environmental fate of ibuprofen.
ID 16749
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=16749
Gilevska, T., Gehre, M., Richnow, H.H. (2015):
Multidimensional isotope analysis of carbon, hydrogen and oxygen as tool for identification of the origin of ibuprofen
J. Pharm. Biomed. Anal. 115 , 410 - 417