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Title (Primary) Glycerophospholipid synthesis and functions in Pseudomonas
Author Kondakova, T.; D'Heygère, F.; Feuilloley, M.J.; Orange, N.; Heipieper, H.J.; Duclairoir Poc, C.;
Journal Chemistry and Physics of Lipids
Year 2015
Department UBT;
Volume 190
Language englisch;
POF III (all) T41;
Keywords Biosynthesis; Lipidomics; Membranes; Phospholipids; Phosphatidylcholine; Lineage; Host; Interactions
UFZ wide themes RU3;
Abstract The genus Pseudomonas is one of the most heterogeneous groups of eubacteria, presents in all major natural environments and in wide range of associations with plants and animals. The wide distribution of these bacteria is due to the use of specific mechanisms to adapt to environmental modifications. Generally, bacterial adaptation is only considered under the aspect of genes and protein expression, but lipids also play a pivotal role in bacterial functioning and homeostasis. This review resumes the mechanisms and regulations of pseudomonal glycerophospholipid synthesis, and the roles of glycerophospholipids in bacterial metabolism and homeostasis. Recently discovered specific pathways of P. aeruginosa lipid synthesis indicate the lineage dependent mechanisms of fatty acids homeostasis. Pseudomonas glycerophospholipids ensure structure functions and play important roles in bacterial adaptation to environmental modifications. The lipidome of Pseudomonas contains a typical eukaryotic glycerophospholipid -phosphatidylcholine-, which is involved in bacteria-host interactions. The ability of Pseudomonas to exploit eukaryotic lipids shows specific and original strategies developed by these microorganisms to succeed in their infectious process. All compiled data provide the demonstration of the importance of studying the Pseudomonas lipidome to inhibit the infectious potential of these highly versatile germs.
ID 16345
Persistent UFZ Identifier https://www.ufz.de/index.php?en=20939&ufzPublicationIdentifier=16345
Kondakova, T., D'Heygère, F., Feuilloley, M.J., Orange, N., Heipieper, H.J., Duclairoir Poc, C. (2015):
Glycerophospholipid synthesis and functions in Pseudomonas
Chem. Phys. Lipids 190 , 27 - 42